{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:20:33Z","timestamp":1791400833293,"version":"4.3.3"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Borrelia burgdorferi<\/jats:italic>\n            , the Lyme disease spirochete, binds the host complement inhibitors factor H (FH) and FH-like protein 1 (FHL-1). Binding of FH\/FHL-1 by the\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            proteins CspA and the OspE-related proteins is thought to enhance resistance to serum-mediated killing. While previous reports have shown that CspA confers serum resistance in\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            , it is unclear whether the OspE-related proteins are relevant in\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            serum resistance when OspE is expressed on the borrelial surface. To assess the role of the OspE-related proteins, we overexpressed them in a serum-sensitive CspA mutant strain. OspE overexpression enhanced serum resistance of the CspA-deficient organisms. Furthermore, FH was more efficiently bound to the\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            surface when OspE was overexpressed. Deposition of complement components C3 and C5b-9 (the membrane attack complex), however, was reduced on the surface of the OspE-overexpressing strain compared to that on the CspA mutant strain. These data demonstrate that OspE proteins expressed on the surface of\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            bind FH and protect the organism from complement deposition and subsequent serum-mediated destruction.\n          <\/jats:p>","DOI":"10.1128\/iai.01274-10","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T03:37:51Z","timestamp":1296531471000},"page":"1451-1457","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["The OspE-Related Proteins Inhibit Complement Deposition and Enhance Serum Resistance of\n            <i>Borrelia burgdorferi<\/i>\n            , the Lyme Disease Spirochete"],"prefix":"10.1128","volume":"79","author":[{"given":"Melisha R.","family":"Kenedy","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrin R.","family":"Akins","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1526-1532.1999"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3847"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3685-3691.2001"},{"key":"e_1_3_2_5_2","first-page":"521","volume":"57","year":"1984","unstructured":"Barbour, A. 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