{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:01:53Z","timestamp":1793149313953,"version":"4.5.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Helicobacter heilmannii<\/jats:named-content>\n            naturally colonizes the stomachs of dogs and cats and has been associated with gastric disorders in humans. Nine feline\n            <jats:named-content content-type=\"genus-species\">Helicobacter<\/jats:named-content>\n            strains, classified as\n            <jats:named-content content-type=\"genus-species\">H. heilmannii<\/jats:named-content>\n            based on\n            <jats:italic>ureAB<\/jats:italic>\n            and 16S rRNA gene sequences, were divided into a highly virulent and a low-virulence group. The genomes of these strains were sequenced to investigate their phylogenetic relationships, to define their gene content and diversity, and to determine if the differences in pathogenicity were associated with the presence or absence of potential virulence genes. The capacities of these helicobacters to bind to the gastric mucosa were investigated as well. Our analyses revealed that the low-virulence strains do not belong to the species\n            <jats:named-content content-type=\"genus-species\">H. heilmannii<\/jats:named-content>\n            but to a novel, closely related species for which we propose the name\n            <jats:named-content content-type=\"genus-species\">Helicobacter ailurogastricus<\/jats:named-content>\n            . Several homologs of\n            <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n            virulence factors, such as IceA1, HrgA, and jhp0562-like glycosyltransferase, are present in\n            <jats:named-content content-type=\"genus-species\">H. heilmannii<\/jats:named-content>\n            but absent in\n            <jats:named-content content-type=\"genus-species\">H. ailurogastricus<\/jats:named-content>\n            . Both species contain a VacA-like autotransporter, for which the passenger domain is remarkably larger in\n            <jats:named-content content-type=\"genus-species\">H. ailurogastricus<\/jats:named-content>\n            than in\n            <jats:named-content content-type=\"genus-species\">H. heilmannii<\/jats:named-content>\n            . In addition,\n            <jats:named-content content-type=\"genus-species\">H. ailurogastricus<\/jats:named-content>\n            shows clear differences in binding to the gastric mucosa compared to\n            <jats:named-content content-type=\"genus-species\">H. heilmannii<\/jats:named-content>\n            . These findings highlight the low-virulence character of this novel\n            <jats:named-content content-type=\"genus-species\">Helicobacter<\/jats:named-content>\n            species.\n          <\/jats:p>","DOI":"10.1128\/iai.01300-15","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T03:04:31Z","timestamp":1446519871000},"page":"293-306","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter heilmannii and Its Closest Relative, the Low-Virulence \u201cHelicobacter ailurogastricus\u201d sp. nov"],"prefix":"10.1128","volume":"84","author":[{"given":"Myrthe","family":"Joosten","sequence":"first","affiliation":[{"name":"Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, 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