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Whether natural coinfections with other macroparasites alter the success of tick feeding, antitick immunity, and the host's reservoir competence for tick-borne pathogens remains to be determined. In a parasitological survey of wild mice in Berlin, Germany, approximately 40% of<jats:named-content content-type=\"genus-species\">Ixodes ricinus<\/jats:named-content>-infested animals simultaneously harbored a nematode of the genus<jats:named-content content-type=\"genus-species\">Heligmosomoides<\/jats:named-content>. We therefore aimed to analyze the immunological impact of the nematode\/tick coinfection as well as its effect on the tick-borne pathogen<jats:named-content content-type=\"genus-species\">Borrelia afzelii<\/jats:named-content>. Hosts experimentally coinfected with<jats:named-content content-type=\"genus-species\">Heligmosomoides polygyrus<\/jats:named-content>and larval\/nymphal<jats:named-content content-type=\"genus-species\">I. ricinus<\/jats:named-content>ticks developed substantially stronger systemic type 2 T helper cell (Th2) responses, on the basis of the levels of GATA-3 and interleukin-13 expression, than mice infected with a single pathogen. During repeated larval infestations, however, anti-tick Th2 reactivity and an observed partial immunity to tick feeding were unaffected by concurrent nematode infections. Importantly, the strong systemic Th2 immune response in coinfected mice did not affect susceptibility to tick-borne<jats:named-content content-type=\"genus-species\">B. afzelii<\/jats:named-content>. An observed trend for decreased local and systemic Th1 reactivity against<jats:named-content content-type=\"genus-species\">B. afzelii<\/jats:named-content>in coinfected mice did not result in a higher spirochete burden, nor did it facilitate bacterial dissemination or induce signs of immunopathology. 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