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Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.\n          <\/jats:p>","DOI":"10.1128\/iai.01326-06","type":"journal-article","created":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T10:40:04Z","timestamp":1165920004000},"page":"1507-1511","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by\n            <i>Mycobacterium bovis<\/i>\n            BCG Pleurisy"],"prefix":"10.1128","volume":"75","author":[{"given":"Heloisa","family":"D'A\u0301vila","sequence":"first","affiliation":[{"name":"Laborato\u0301rio de Imunofarmacologia, Departamento de Fisiologia e Farmacodina\u0302mica, Instituto Oswaldo Cruz, Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patri\u0301cia E.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Imunofarmacologia, Departamento de Fisiologia e Farmacodina\u0302mica, Instituto Oswaldo Cruz, Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nata\u0301lia R.","family":"Roque","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Imunofarmacologia, Departamento de Fisiologia e Farmacodina\u0302mica, Instituto Oswaldo Cruz, Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo C.","family":"Castro-Faria-Neto","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Imunofarmacologia, Departamento de Fisiologia e Farmacodina\u0302mica, Instituto Oswaldo Cruz, Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patri\u0301cia T.","family":"Bozza","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Imunofarmacologia, Departamento de Fisiologia e Farmacodina\u0302mica, Instituto Oswaldo Cruz, Fundac\u0327a\u0303o Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00676.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101436200"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.2.151"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.06.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.987"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.9.3009-3014.1991"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.3087"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.525.525"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)90096-4"},{"key":"e_1_3_2_11_2","first-page":"147","volume":"10","year":"1999","unstructured":"Erb, K. 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