{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:16:09Z","timestamp":1672899369202},"reference-count":60,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacillus cereus<\/jats:named-content>\n            strains harboring a pXO1-like virulence plasmid cause respiratory anthrax-like disease in humans, particularly in welders. We developed mouse models for intraperitoneal as well as aerosol challenge with spores of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. cereus<\/jats:named-content>\n            G9241, harboring pBCXO1 and pBC218 virulence plasmids. Compared to wild-type\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. cereus<\/jats:named-content>\n            G9241, spores with a deletion of the pBCXO1-carried protective antigen gene (\n            <jats:italic>pagA1<\/jats:italic>\n            ) were severely attenuated, whereas spores with a deletion of the pBC218-carried protective antigen homologue (\n            <jats:italic>pagA2<\/jats:italic>\n            ) were not. Anthrax vaccine adsorbed (AVA) immunization raised antibodies that bound and neutralized the\n            <jats:italic>pagA1<\/jats:italic>\n            -encoded protective antigen (PA1) but not the PA2 orthologue encoded by\n            <jats:italic>pagA2<\/jats:italic>\n            . AVA immunization protected mice against a lethal challenge with spores from\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. cereus<\/jats:named-content>\n            G9241 or\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. cereus<\/jats:named-content>\n            Elc4, a strain that had been isolated from a fatal case of anthrax-like disease. As the pathogenesis of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. cereus<\/jats:named-content>\n            anthrax-like disease in mice is dependent on\n            <jats:italic>pagA1<\/jats:italic>\n            and PA-neutralizing antibodies provide protection, AVA immunization may also protect humans from respiratory anthrax-like death.\n          <\/jats:p>","DOI":"10.1128\/iai.01346-12","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T04:54:12Z","timestamp":1358225652000},"page":"1008-1017","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Vaccine Protection against Bacillus cereus-Mediated Respiratory Anthrax-Like Disease in Mice"],"prefix":"10.1128","volume":"81","author":[{"given":"So-Young","family":"Oh","sequence":"first","affiliation":[{"name":"Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, Illinois, USA"},{"name":"Department of Microbiology, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Maier","sequence":"additional","affiliation":[{"name":"Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, Illinois, USA"},{"name":"Department of Microbiology, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, Illinois, USA"},{"name":"Department of Microbiology, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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