{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:18:34Z","timestamp":1767892714167,"version":"3.49.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The tumor necrosis factor receptor family molecule 4-1BB (CD137) has diverse roles in adaptive and innate immune responses. However, little is known of its role in bacterial infections. Previously, we showed that 4-1BB-deficient mice have enhanced susceptibility to<jats:italic>Listeria monocytogenes<\/jats:italic>infection, and mice pretreated with agonistic anti-4-1BB antibody (3E1) were much more resistant to<jats:italic>L. monocytogenes<\/jats:italic>infection than mice treated with control antibody. In this study, we report that stimulating 4-1BB by administering 3E1 in the early phase of<jats:italic>L. monocytogenes<\/jats:italic>infection is critical for promoting the survival of mice by inducing rapid infiltration of neutrophils and monocytes into<jats:italic>L. monocytogenes<\/jats:italic>-infected livers. The levels of tumor necrosis factor alpha, interleukin 6, and monocyte chemoattractant protein 1 in the livers of 3E1-treated mice increased as early as 30 min postinfection and peaked by 1 to 2 h, while those in mice treated with control antibody started to increase only at 16 h postinfection. Monocytes and neutrophils from the 3E1-treated mice had higher levels of activation markers, phagocytic activity, and reactive oxygen species than those from control mice. In vitro stimulation of 4-1BB induced the production of the inflammatory cytokines\/chemokines of neutrophils, but not those of monocytes. These results suggest that 4-1BB stimulation of neutrophils in the early phase of<jats:italic>L. monocytogenes<\/jats:italic>infection causes rapid production of inflammatory cytokines\/chemokines and that the subsequent infiltration of neutrophils and monocytes is crucial for eliminating the infecting<jats:italic>L. monocytogenes<\/jats:italic>.<\/jats:p>","DOI":"10.1128\/iai.01350-08","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T01:34:43Z","timestamp":1235439283000},"page":"2168-2176","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Stimulation of the Molecule 4-1BB Enhances Host Defense against<i>Listeria monocytogenes<\/i>Infection in Mice by Inducing Rapid Infiltration and Activation of Neutrophils and Monocytes"],"prefix":"10.1128","volume":"77","author":[{"given":"Sang-Chul","family":"Lee","sequence":"first","affiliation":[{"name":"Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-A","family":"Ju","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boo-Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook-Kyoung","family":"Heo","sequence":"additional","affiliation":[{"name":"Cardiovascular Medical Research Center and Department of Prescriptionology, University of Dongguk, Gyeongju City, Gyeongbuk 780-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bio-Technology, Hoseo University, 29-1 Sechuli, Baebang-Myun, Asan City, Chungnam-Do 336-795, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Min","family":"Park","sequence":"additional","affiliation":[{"name":"Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang Tam","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hee","family":"Suh","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682-714, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Sam","family":"Kim","sequence":"additional","affiliation":[{"name":"Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2004.02.006"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.4991"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8036519"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060045"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017407.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.152.4.1836","volume":"152","year":"1994","unstructured":"Czuprynski, C. 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