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Spherules are the tissue form of\n            <jats:named-content content-type=\"genus-species\">Coccidioides<\/jats:named-content>\n            , and we determined that the MR on bone marrow-derived dendritic cells (BMDC) was important for recognition of spherules (formalin-killed spherules [FKS]) and for secretion of interleukin 10 (IL-10) and proinflammatory cytokines in response to FKS by both elicited macrophages and BMDC. Infected MR knockout (KO) mice produced more IL-10 in their lungs than did B6 mice, and MR KO mice also made more protective Th-17 cytokines. In contrast to the MR, Dectin-2 was not required for recognition of FKS by BMDC or for the production of cytokines by BMDC in response to FKS. However, Dectin-2 KO was required for stimulation of elicited peritoneal macrophages. Despite that, lung cytokine levels were not significantly different in Dectin-2 KO mice and B6 mice 14 days after infection, except for IL-1\u03b2, which was higher in Dectin-2 KO lungs. Although both Dectin-2\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            and MR\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            myeloid cells had reduced proinflammatory cytokine responses to FKS\n            <jats:italic>in vitro<\/jats:italic>\n            , neither MR nor Dectin-2 deficiency reduced the resistance of B6 mice to pulmonary coccidioidomycosis.\n          <\/jats:p>","DOI":"10.1128\/iai.01355-13","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T03:47:19Z","timestamp":1388461639000},"page":"1147-1156","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Neither Dectin-2 nor the Mannose Receptor Is Required for Resistance to Coccidioides immitis in Mice"],"prefix":"10.1128","volume":"82","author":[{"given":"Suganya","family":"Viriyakosol","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria del Pilar","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinobu","family":"Saijo","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Fierer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA"},{"name":"Infectious Diseases Service, VA Healthcare San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02230-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0203.960305"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1206.060028"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90054-S"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20654"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.04.022"},{"key":"e_1_3_2_8_2","volume-title":"Coccidioidomycosis","author":"Fiese MJ","year":"1958","unstructured":"FieseMJ. 1958. 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