{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:26:26Z","timestamp":1791275186581,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 10\n            <jats:sup>7<\/jats:sup>\n            CFU of\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            results in about 50% stillbirths. Ten of 33 pregnant rhesus monkeys exposed orally to a single dose of 10\n            <jats:sup>2<\/jats:sup>\n            to 10\n            <jats:sup>10<\/jats:sup>\n            CFU of\n            <jats:italic>L<\/jats:italic>\n            .\n            <jats:italic>monocytogenes<\/jats:italic>\n            had stillbirths. A log-logistic model predicts a dose affecting 50% of animals at 10\n            <jats:sup>7<\/jats:sup>\n            CFU, comparable to an estimated 10\n            <jats:sup>6<\/jats:sup>\n            CFU based on an outbreak among pregnant women but much less than the extrapolated estimate (10\n            <jats:sup>13<\/jats:sup>\n            CFU) from the FDA-U.S. Department of Agriculture-CDC risk assessment using an exponential curve based on mouse data. Exposure and etiology of the disease are the same in humans and primates but not in mice. This information will aid in risk assessment, assist policy makers, and provide a model for mechanistic studies of\n            <jats:italic>L<\/jats:italic>\n            .\n            <jats:italic>monocytogenes<\/jats:italic>\n            -induced stillbirths.\n          <\/jats:p>","DOI":"10.1128\/iai.01366-06","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T01:34:33Z","timestamp":1197336873000},"page":"726-731","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":67,"title":["Dose-Response Model for\n            <i>Listeria monocytogenes<\/i>\n            -Induced Stillbirths in Nonhuman Primates"],"prefix":"10.1128","volume":"76","author":[{"given":"Mary Alice","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia 30602"},{"name":"Center for Food Safety, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, Georgia 30223"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Center for Food Safety, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, Georgia 30223"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn O.","family":"Ware","sequence":"additional","affiliation":[{"name":"Experimental Statistics, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold M.","family":"McClure","sequence":"additional","affiliation":[{"name":"Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Raybourne","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration, Laurel, Maryland 20708"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutan","family":"Mytle","sequence":"additional","affiliation":[{"name":"Center for Food Safety, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, Georgia 30223"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Doyle","sequence":"additional","affiliation":[{"name":"Center for Food Safety, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, Georgia 30223"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421702"},{"key":"e_1_3_2_3_2","first-page":"251","volume":"41","year":"1992","unstructured":"Centers for Disease Control and Prevention. 1992. Update: foodborne listeriosis\u2014United States, 1988-1990. Morb. Mortal. Wkly. Rep.41:251, 257-258.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_4_2","unstructured":"USDA\/FSIS microbiology laboratory guide book 1998"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360204"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-69.11.2664"},{"key":"e_1_3_2_7_2","unstructured":"Risk assessment of Listeria monocytogenes in ready-to-eat foods. Interpretative summary. 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