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To investigate the \u03b2 chain (V\u03b2) specificities of each of these toxins, TSST-1 and all known<jats:italic>S. aureus<\/jats:italic>enterotoxins and enterotoxin-like toxins were produced as recombinant proteins and tested for their ability to induce the selective in vitro expansion of human T cells bearing particular V\u03b2 T-cell receptors (TCR). Although redundancies were observed between the toxins and the V\u03b2 populations, each toxin induced the expansion of distinct V\u03b2 subsets, including enterotoxin H and enterotoxin-like toxin J. Surprisingly, the V\u03b2 signatures were not associated with a specific phylogenic group of toxins. Interestingly, each human V\u03b2 analyzed in this study was stimulated by at least one staphylococcal superantigen, suggesting that the bacterium derives a selective advantage from targeting the entire human TCR V\u03b2 panel.<\/jats:p>","DOI":"10.1128\/iai.01388-08","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T01:59:01Z","timestamp":1236045541000},"page":"2043-2050","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["<i>Staphylococcus aureus<\/i>Superantigens Elicit Redundant and Extensive Human V\u03b2 Patterns"],"prefix":"10.1128","volume":"77","author":[{"given":"Damien","family":"Thomas","sequence":"first","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dauwalder","sequence":"additional","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Brun","sequence":"additional","affiliation":[{"name":"Laboratoire d'Etude de la Dynamique des Prote\u0301omes, U880 CEA\/DSV\/iRTSV\/INSERM\/UJF, 17 Rue des Martyrs, 38054 Grenoble Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Badiou","sequence":"additional","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Ferry","sequence":"additional","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Etienne","sequence":"additional","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Vandenesch","sequence":"additional","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Lina","sequence":"additional","affiliation":[{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, INSERM U851, IFR128 Laennec, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08713-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90447-3"},{"key":"e_1_3_2_4_2","first-page":"464","year":"2006","unstructured":"Bohach, G. 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