{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:39:55Z","timestamp":1771666795852,"version":"3.50.1"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Sepsis caused by\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            is increasing in incidence. With the alarming use of antibiotics,\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            is prone to become methicillin resistant. Antibiotics are the only widely used pharmacological treatment for sepsis. Interestingly, mice fed high-fat diet (HFD) rich in polyunsaturated fatty acids have better survival of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            -induced sepsis than mice fed HFD rich in saturated fatty acids (HFD-S). To investigate what component of polyunsaturated fatty acids, i.e., omega-3 or omega-6 fatty acids, exerts beneficial effects on the survival of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            -induced sepsis, mice were fed HFD rich in omega-3 or omega-6 fatty acids for 8 weeks prior to inoculation with\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            . Further, mice fed HFD-S were treated with omega-3 fatty acid metabolites known as resolvins. Mice fed HFD rich in omega-3 fatty acids had increased survival and decreased bacterial loads compared to those for mice fed HFD-S after\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            -induced sepsis. Furthermore, the bacterial load was decreased in resolvin-treated mice fed HFD-S after\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            -induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            -induced sepsis by reversing the deleterious effect of HFD-S on mouse survival.\n          <\/jats:p>","DOI":"10.1128\/iai.01391-15","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T04:29:23Z","timestamp":1454992163000},"page":"1205-1213","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis"],"prefix":"10.1128","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2614-1138","authenticated-orcid":false,"given":"Sara L.","family":"Svahn","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus A.","family":"Ulleryd","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Grahnemo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden"},{"name":"Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"St\u00e5hlman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bor\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Mathematical Statistics, Chalmers University of Technology, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John-Olov","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburgy, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043632"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2012.697151"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01589.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1145"},{"key":"e_1_3_2_7_2","first-page":"821","article-title":"New approaches for empiric therapy in Gram-positive sepsis","volume":"77","author":"Bassetti M","year":"2011","unstructured":"Bassetti M, Ginocchio F, Giacobbe DR. 2011. 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