{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:16:23Z","timestamp":1790162183801,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Protective immunity against tuberculosis (TB) requires the integrated response of a network of lymphocytes. Both gamma interferon (IFN-\u03b3)- and interleukin 17 (IL-17)-secreting CD4<jats:sup>+<\/jats:sup>T cells have been identified in subjects with latent TB infection and during experimental<jats:italic>Mycobacterium tuberculosis<\/jats:italic>infection, but the contribution of Th17 cells to protective immunity is unclear. To examine their protective effects<jats:italic>in vivo<\/jats:italic>, we transferred mycobacterium-specific IL-17- and IFN-\u03b3-secreting CD4<jats:sup>+<\/jats:sup>T cells isolated from<jats:italic>M. tuberculosis<\/jats:italic>BCG-immunized IL-12p40<jats:sup>\u2212\/\u2212<\/jats:sup>and IFN-\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>or wild-type mice, respectively, into<jats:italic>M. tuberculosis<\/jats:italic>-infected IL-12p40<jats:sup>\u2212\/\u2212<\/jats:sup>or RAG<jats:sup>\u2212\/\u2212<\/jats:sup>mice. In the absence of IL-12 and IL-23, neither IL-17-secreting (Th17) nor IFN-\u03b3-secreting (Th1) BCG-specific T cells expanded or provided protection against<jats:italic>M. tuberculosis<\/jats:italic>. In RAG<jats:sup>\u2212\/\u2212<\/jats:sup>recipients with an intact IL-12\/IL-23 axis, both Th17 and Th1 cells were activated and induced significant protection against<jats:italic>M. tuberculosis<\/jats:italic>. The reduction in the bacterial load following transfer of IFN-\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>Th17 cells was associated with significant prolongation of survival compared to recipients of nai\u0308ve IFN-\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup>T cells. This effect was at the cost of an increased inflammatory infiltrate characterized by an excess of neutrophils. Therefore, Th17 cells can provide IFN-\u03b3-independent protection against<jats:italic>M. tuberculosis<\/jats:italic>, and this effect may contribute to the early control of<jats:italic>M. tuberculosis<\/jats:italic>infection.<\/jats:p>","DOI":"10.1128\/iai.01392-09","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T02:16:02Z","timestamp":1280801762000},"page":"4187-4194","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":121,"title":["<i>Mycobacterium bovis<\/i>BCG-Specific Th17 Cells Confer Partial Protection against<i>Mycobacterium tuberculosis<\/i>Infection in the Absence of Gamma Interferon"],"prefix":"10.1128","volume":"78","author":[{"given":"Teresa M.","family":"Wozniak","sequence":"first","affiliation":[{"name":"Mycobacterial Research Program, Centenary Institute, Locked Bag No. 6, Newtown, NSW 2042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette M.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Mycobacterial Research Program, Centenary Institute, Locked Bag No. 6, Newtown, NSW 2042"},{"name":"Discipline of Medicine, Central Clinical School, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Mycobacterial Research Program, Centenary Institute, Locked Bag No. 6, Newtown, NSW 2042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick J.","family":"Britton","sequence":"additional","affiliation":[{"name":"Mycobacterial Research Program, Centenary Institute, Locked Bag No. 6, Newtown, NSW 2042"},{"name":"Discipline of Medicine, Central Clinical School, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.2122-2127.1998"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081463"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1322"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1416"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7086"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092315"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2827"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","volume":"160","year":"1998","unstructured":"Jovanovic, D. 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