{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:01:44Z","timestamp":1791180104691,"version":"4.1.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            serotype 4 strain TIGR4.\n          <\/jats:p>","DOI":"10.1128\/iai.01400-06","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T01:33:53Z","timestamp":1165282433000},"page":"1059-1062","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":122,"title":["<i>Streptococcus pneumoniae<\/i>\n            Pilus Subunits Protect Mice against Lethal Challenge"],"prefix":"10.1128","volume":"75","author":[{"given":"Claudia","family":"Gianfaldoni","sequence":"first","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Censini","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hilleringmann","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Moschioni","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Facciotti","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Pansegrau","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vega","family":"Masignani","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Covacci","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino","family":"Rappuoli","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le Anne","family":"Barocchi","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511017103"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.038"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)00938-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-14"},{"key":"e_1_3_2_6_2","first-page":"1389","volume":"45","year":"2002","unstructured":"Hava, D. L., and A. Camilli. 2002. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol. Microbiol.45:1389-1406.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(04)00442-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2453-2456.2006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68703-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109869"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.06.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408410600822942"},{"key":"e_1_3_2_13_2","first-page":"50","volume":"4","year":"2006","unstructured":"Telford, J. L., M. Barocchi, I. Margarit, R. Rappuoli, and G. Grandi. 2006. Pili in Gram-positive pathogens. Nat. Rev. Microbiol.4:50.","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2005.05.008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03782.x"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01400-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01400-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:50:36Z","timestamp":1646463036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01400-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1128\/IAI.01400-06"],"URL":"https:\/\/doi.org\/10.1128\/iai.01400-06","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"2006-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}