{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:26:24Z","timestamp":1790907984651,"version":"4.1.0"},"reference-count":75,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>Borrelia burgdorferi<\/jats:italic>\n            BmpA outer surface protein plays a significant role in mammalian infection by the Lyme disease spirochete and is an important antigen for the serodiagnosis of human infection.\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            adheres to host extracellular matrix components, including laminin. The results of our studies indicate that BmpA and its three paralogous proteins, BmpB, BmpC, and BmpD, all bind to mammalian laminin. BmpA did not bind mammalian type I or type IV collagens or fibronectin. BmpA-directed antibodies significantly inhibited the adherence of live\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            to laminin. The laminin-binding domain of BmpA was mapped to the carboxy-terminal 80 amino acids. Solubilized collagen inhibited BmpA-laminin binding, suggesting interactions through the collagen-binding domains of laminin. These results, together with previous data, indicate that BmpA and its paralogs are targets for the development of preventative and curative therapies for Lyme disease.\n          <\/jats:p>","DOI":"10.1128\/iai.01420-08","type":"journal-article","created":{"date-parts":[[2009,8,25]],"date-time":"2009-08-25T01:11:00Z","timestamp":1251162660000},"page":"4940-4946","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":67,"title":["<i>Borrelia burgdorferi<\/i>\n            BmpA Is a Laminin-Binding Protein"],"prefix":"10.1128","volume":"77","author":[{"given":"Ashutosh","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Brissette","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Bowman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3847"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05924.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07204.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1996.tb08594.x"},{"key":"e_1_3_2_6_2","first-page":"1","year":"1995","unstructured":"Association of State and Territorial Public Health Laboratory Directors. 1995. Recommendations, p. 1-5. In Second National Conference on Serologic Diagnosis of Lyme Disease. Association of Public Health Laboratories, Washington, DC.","journal-title":"Association of Public Health Laboratories"},{"key":"e_1_3_2_7_2","first-page":"223","year":"1992","unstructured":"Barthold, S. W., M. de Souza, E. Fikrig, and D. H. Persing. 1992. Lyme borreliosis in the laboratory mouse, p. 223-242. In S. E. Schutzer (ed.), Lyme disease: molecular and immunologic approaches. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","journal-title":"Lyme disease: molecular and immunologic approaches"},{"key":"e_1_3_2_8_2","first-page":"959","volume":"143","year":"1993","unstructured":"Barthold, S. W., M. S. de Souza, J. L. Janotka, A. L. Smith, and D. H. Persing. 1993. Chronic Lyme borreliosis in the laboratory mouse. Am. J. Pathol.143:959-972.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_9_2","first-page":"263","volume":"139","year":"1991","unstructured":"Barthold, S. W., D. H. Persing, A. L. Armstrong, and R. A. Peeples. 1991. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. Am. J. Pathol.139:263-273.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.605"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00227-09"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.09.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01133-08"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.024604-0"},{"key":"e_1_3_2_15_2","first-page":"935","volume":"12","year":"2005","unstructured":"Bryksin, A. V., H. P. Godfrey, C. A. Carbonaro, G. P. Wormser, M. E. Aguero-Rosenfeld, and F. C. Cabello. 2005. Borrelia burgdorferi BmpA, BmpB, and BmpD proteins are expressed in human infection and contribute to P39 immunoblot reactivity in patients with Lyme disease. Clin. Diagn. Lab. Immunol.12:935-940.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00604-07"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.06.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.7087-7098.2003"},{"key":"e_1_3_2_19_2","first-page":"590","volume":"44","year":"1995","unstructured":"Centers for Disease Control and Prevention. 1995. Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease. Morb. Mortal. Wkly. Rep.44:590-591.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.7.2478-2484.1995"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5063-5072.2004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31875.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.3455-3459.2001"},{"key":"e_1_3_2_25_2","first-page":"3","volume":"141","year":"1992","unstructured":"Defosse, D. L., P. H. Duray, and R. C. Johnson. 1992. The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis. Am. J. Pathol.141:3-10.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511405200"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-23-3-261"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.271"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02220.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/1046-5928(90)90011-M"},{"key":"e_1_3_2_31_2","first-page":"734","volume":"20","year":"1993","unstructured":"Fawcett, P. T., C. Rose, K. M. Gibney, C. A. Chase, B. Kiehl, and R. A. Doughty. 1993. Detection of antibodies to the recombinant P39 protein of Borrelia burgdorferi using enzyme immunoassay and immunoblotting. J. Rheumatol.20:734-738.","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<151::AID-ANR19>3.0.CO;2-E"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00038-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.9.3467-3472.1995"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01639-07"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361118"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007994200"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.42.1.114-160.1978"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.46.1.220-223.1984"},{"key":"e_1_3_2_41_2","first-page":"152","volume":"293","year":"2004","unstructured":"Kraiczy, P., K. Hartmann, J. Hellwage, C. Skerka, V. Brade, P. F. Zipfel, R. Wallich, and B. Stevenson. 2004. Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi. Int. J. Med. Microbiol.293(S37):152-157.","journal-title":"Int. J. Med. Microbiol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.06.016"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.36.010191.003103"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3587-3596.2003"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6943-6952.2003"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030033"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00189-06"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500187"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.52.128"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070962"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.01127.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(86)90132-5"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.25.13865"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.2.490-498.1988"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.4.671"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.8.2592-2600.2005"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.4.1259-1264.1996"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.11.002"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.6.1018"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200401058"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.1.382-388.2000"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2909"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.3.735-738.1992"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.10.4523-4526.1993"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.236-243.1991"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb06917.x"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.6.1329-1337.1990"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3654-3661.1997"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118295"},{"key":"e_1_3_2_70_2","first-page":"354","year":"2006","unstructured":"Stevenson, B., T. Bykowski, A. E. Cooley, K. Babb, J. C. Miller, M. E. Woodman, K. von Lackum, and S. P. Riley. 2006. The Lyme disease spirochete Erp lipoprotein family: structure, function and regulation of expression, p. 354-372. In F. C. Cabello, H. P. Godfrey, and D. Hulinska (ed.), Molecular biology of spirochetes. IOS Press, Amsterdam, The Netherlands.","journal-title":"Molecular biology of spirochetes"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal\/pone.0001188"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.2.491-497.2002"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.07.029"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031960"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3138-3146.2004"},{"key":"e_1_3_2_76_2","first-page":"12C.1.1","year":"2007","unstructured":"Z\u00fcckert, W. R. 2007. Laboratory maintenance of Borrelia burgdorferi, p. 12C.1.1-12C.1.10. In R. Coico et al. (ed.), Current protocols in microbiology. Wiley, Hoboken, NJ.","journal-title":"Current protocols in microbiology"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01420-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01420-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T09:21:16Z","timestamp":1646472076000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01420-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1128\/IAI.01420-08"],"URL":"https:\/\/doi.org\/10.1128\/iai.01420-08","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"2008-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}