{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:03:35Z","timestamp":1785229415854,"version":"3.55.0"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Campylobacter jejuni<\/jats:italic>\n            is a leading cause of bacterial gastroenteritis in humans throughout the world, but infection of animals, especially poultry, results in a commensal colonization of the intestines. We previously found that a mutant lacking\n            <jats:italic>docA<\/jats:italic>\n            , which encodes a putative cytochrome\n            <jats:italic>c<\/jats:italic>\n            peroxidase (CCP), demonstrates up to a 10\n            <jats:sup>5<\/jats:sup>\n            -fold reduction in colonization of the chick cecum compared to wild-type\n            <jats:italic>C. jejuni<\/jats:italic>\n            strain 81-176. Predictions from genomic sequences identified CJJ0382 as a second locus in\n            <jats:italic>C. jejuni<\/jats:italic>\n            encoding a CCP, making the bacterium unusual in having two putative CCPs. To understand what advantages are imparted by having two putative CCPs, we compared the colonization requirements of\n            <jats:italic>C. jejuni<\/jats:italic>\n            mutants lacking DocA or Cjj0382. Unlike the \u0394\n            <jats:italic>docA<\/jats:italic>\n            mutant, a \u0394CJJ0382 mutant demonstrates a maximal 50-fold colonization defect that is dependent on the inoculum dose. The colonization differences of mutants lacking DocA or Cjj0382 suggest that the two predicted CCPs are unlikely to perform redundant functions during in vivo growth. In the characterizations of DocA and Cjj0382, we found that they are stable periplasmic proteins with an apparent heme-dependent peroxidase activity, which are characteristics of bacterial CCPs. However, the peroxidase activities of the proteins do not appear to contribute to resistance to hydrogen peroxide. Instead, we found that resistance to hydrogen peroxide in\n            <jats:italic>C. jejuni<\/jats:italic>\n            is mostly attributed to the cytoplasmic catalase KatA. Our data suggest that DocA and Cjj0382 have characteristics of CCPs but likely perform different physiological functions for the bacterium in colonization that are not related to resisting oxidative stress.\n          <\/jats:p>","DOI":"10.1128\/iai.01430-07","type":"journal-article","created":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T02:31:18Z","timestamp":1197945078000},"page":"1105-1114","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Characterization of Two Putative Cytochrome\n            <i>c<\/i>\n            Peroxidases of\n            <i>Campylobacter jejuni<\/i>\n            Involved in Promoting Commensal Colonization of Poultry"],"prefix":"10.1128","volume":"76","author":[{"given":"Lacey K.","family":"Bingham-Ramos","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Hendrixson","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(06)52002-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.54.10.2365-2370.1988"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.3.472"},{"key":"e_1_3_2_5_2","first-page":"392","volume":"55","year":"2006","unstructured":"Centers for Disease Control and Prevention. 2006. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food\u201410 states, United States, 2005. Morb. Mortal. Wkly. Rep.55:392-395.","journal-title":"Morb. Mortal. Wkly. 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M. Allos, and T. W. Ho. 2000. Campylobacter jejuni infection and the association with Guillain-Barre syndrome, p. 155-176. In I. Nachamkin and M. J. Blaser (ed.), Campylobacter. ASM Press, Washington, DC.","journal-title":"Campylobacter."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/35001088"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330190"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.6.2540-2546.1999"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1995.tb07821.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.15.4187-4196.2002"},{"key":"e_1_3_2_31_2","first-page":"69","year":"2000","unstructured":"Skirrow, M. B., and M. J. Blaser. 2000. Clinical Aspects of Campylobacter infection, p. 69-88. In I. Nachamkin and M. J. Blaser (ed.), Campylobacter. 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