{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:16:55Z","timestamp":1790666215235,"version":"4.1.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lyme disease, caused by\n                    <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n                    , is the most commonly reported vector-borne disease in the United States. Many patients treated for early Lyme disease incur another infection in subsequent years, suggesting that previous exposure to\n                    <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n                    may not elicit a protective immune response. However, identical strains are almost never detected from patients who have been infected multiple times, suggesting that\n                    <jats:named-content content-type=\"genus-species\">B. burgdorferi<\/jats:named-content>\n                    exposure may elicit strain-specific immunity. Probabilistic and simulation models assuming biologically realistic data derived from patients in the northeastern United States suggest that patients treated for early Lyme disease develop protective immunity that is strain specific and lasts for at least 6 years.\n                  <\/jats:p>","DOI":"10.1128\/iai.01451-13","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:32:51Z","timestamp":1389659571000},"page":"1408-1413","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Evidence for Strain-Specific Immunity in Patients Treated for Early Lyme Disease"],"prefix":"10.1128","volume":"82","author":[{"given":"Camilo E.","family":"Khatchikian","sequence":"first","affiliation":[{"name":"Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Nadelman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Brisson","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"ND-579","article-title":"Lyme disease\u2014United States","volume":"62","author":"CDC","year":"2013","unstructured":"CDC. 2013. Lyme disease\u2014United States. MMWR Morb. Mortal. Wkly. Rep. 62:ND-579\u2013ND-592.","journal-title":"MMWR Morb. Mortal. Wkly. 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