{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:13:38Z","timestamp":1790781218999,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Both\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            and \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Helicobacter heilmannii\u201d infections are associated with peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (MALT) lymphomas. However, good animal models of\n            <jats:italic>H. pylori<\/jats:italic>\n            clinical diseases are rare. In this study, we aimed to establish an animal model of \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Helicobacter heilmannii\u201d gastric MALT lymphoma. We used a urease-positive gastric mucosal and mucus homogenate from a cynomolgus monkey maintained in C57BL\/6 mouse stomachs. The bacterium in the homogenate was identified as \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Helicobacter heilmannii\u201d based on a DNA sequence analysis of the 16S rRNA and urease genes. Mucosal and mucus homogenates were used to inoculate C57BL\/6 mice, which were then examined for 24 months. We observed a gradual increase in the surface area of protrusive lesions in almost all infected C57BL\/6 mouse fundic stomachs 6 months after infection. Light microscopic observations revealed an accumulation of B lymphocytes along with destruction of glandular elements and the presence of lymphoepithelial lesions consistent with low-grade MALT lymphomas. Electron microscopic observation revealed numerous \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Helicobacter heilmannii\u201d bacilli in the fundic glandular lumen, the intracellular canaliculi, and the cytoplasm of intact cells, as well as damaged parietal cells. In conclusion, \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Helicobacter heilmannii\u201d induced gastric MALT lymphomas in almost 100% of infected C57BL\/6 mice after a 6-month period associated with the destruction of parietal cells.\n          <\/jats:p>","DOI":"10.1128\/iai.01459-06","type":"journal-article","created":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T01:39:15Z","timestamp":1167356355000},"page":"1214-1222","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["\u201c\n            <i>Candidatus<\/i>\n            Helicobacter heilmannii\u201d from a Cynomolgus Monkey Induces Gastric Mucosa-Associated Lymphoid Tissue Lymphomas in C57BL\/6 Mice"],"prefix":"10.1128","volume":"75","author":[{"given":"Masahiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somay Yamagata","family":"Murayama","sequence":"additional","affiliation":[{"name":"Kitasato Institute for Life Sciences &amp; Graduate School of Infection Control Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan"},{"name":"Center for Basic Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kitasato Institute Hospital, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Sekiya","sequence":"additional","affiliation":[{"name":"Center for Basic Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Kitasato Institute for Life Sciences &amp; Graduate School of Infection Control Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan"},{"name":"Center for Basic Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsufumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Kitasato Institute for Life Sciences &amp; Graduate School of Infection Control Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan"},{"name":"Center for Basic Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Kitasato Institute for Life Sciences &amp; Graduate School of Infection Control Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan"},{"name":"Center for Basic Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Hibi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Tsuchimoto","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences"},{"name":"Department of Internal Medicine, Kitasato Institute Hospital, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Matsui","sequence":"additional","affiliation":[{"name":"Kitasato Institute for Life Sciences &amp; Graduate School of Infection Control Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan"},{"name":"Center for Basic Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01586196"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(02)00547-3"},{"key":"e_1_3_2_5_2","first-page":"1405","volume":"160","year":"1994","unstructured":"Dubois, A., L. 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