{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:53:51Z","timestamp":1789966431173,"version":"4.0.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori is<\/jats:italic>\n                    the etiological agent of human chronic gastritis, a condition seen as a precursor to the development of gastrointestinal ulcers or gastric cancer. This study utilized the murine model of chronic\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection to characterize the role of macrophages in the induction of specific immune responses and gastritis and in the control of the bacterial burden following\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection and vaccination. Drug-loaded liposomes were injected intravenously to deplete macrophages from C57BL\/6 mice, and effective removal of CD11b\n                    <jats:sup>+<\/jats:sup>\n                    cells from the spleens and stomachs of mice was confirmed by immunofluorescence microscopy. Transient elimination of macrophages from C57BL\/6 mice during the early period of infection reduced the gastric pathology induced by\n                    <jats:italic>H. pylori<\/jats:italic>\n                    SS1 but did not affect the bacterial load in the stomach. These data suggest that macrophages are important to the severity of gastric inflammation during\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1128\/iai.01481-07","type":"journal-article","created":{"date-parts":[[2008,3,10]],"date-time":"2008-03-10T21:05:47Z","timestamp":1205183147000},"page":"2235-2239","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":85,"title":["Macrophages Are Mediators of Gastritis in Acute\n                    <i>Helicobacter pylori<\/i>\n                    Infection in C57BL\/6 Mice"],"prefix":"10.1128","volume":"76","author":[{"given":"Maria","family":"Kaparakis","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and the NHMRC Bacterial Pathogenesis Group, The University of Melbourne, Parkville, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Walduck","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and the NHMRC Bacterial Pathogenesis Group, The University of Melbourne, Parkville, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and the NHMRC Bacterial Pathogenesis Group, The University of Melbourne, Parkville, Victoria 3010, Australia"},{"name":"CRC for Vaccine Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Alfred Hospital, Prahran, Victoria 3181, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"van Rooijen","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Vrije Universiteit VUMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Pearse","sequence":"additional","affiliation":[{"name":"CRC for Vaccine Technology"},{"name":"CSL Limited, Poplar Rd., Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odilia L. C.","family":"Wijburg","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and the NHMRC Bacterial Pathogenesis Group, The University of Melbourne, Parkville, Victoria 3010, Australia"},{"name":"CRC for Vaccine Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Strugnell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and the NHMRC Bacterial Pathogenesis Group, The University of Melbourne, Parkville, Victoria 3010, Australia"},{"name":"CRC for Vaccine Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00226.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00232.x"},{"key":"e_1_3_2_4_2","first-page":"181","volume":"241","year":"1999","unstructured":"Blanchard, T. G., S. J. Czinn, and J. G. 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