{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:40:26Z","timestamp":1791852026163,"version":"4.3.4"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The obligatory intracellular bacterium<jats:italic>Chlamydophila psittaci<\/jats:italic>is the causative agent of psittacosis in birds and humans. The capability of this zoonotic pathogen to develop a persistent phase is likely to play a role in chronicity of infections, as well as in failure of antibiotic therapy and immunoprophylaxis. To elucidate three different in vitro models for transition of<jats:italic>C. psittaci<\/jats:italic>to persistence (iron depletion, penicillin G treatment, and gamma interferon [IFN-\u03b3] exposure), a set of 27 genes was examined by mRNA expression analysis using quantitative real-time PCR. While the phenotypical characteristics were the same as in other chlamydiae, i.e., aberrant morphology of reticulate bodies, loss of cultivability, and rescue of infectivity upon removal of inducers, the transcriptional response of<jats:italic>C. psittaci<\/jats:italic>to persistence-inducing factors included several new and distinctive features. Consistent downregulation of membrane proteins, chlamydial sigma factors, cell division protein, and reticulate body-elementary body differentiation proteins from 24 h postinfection onward proved to be a general feature of<jats:italic>C. psittaci<\/jats:italic>persistence. However, other genes displayed considerable variations in response patterns from one model to another, which suggests that there is no persistence model per se. In contrast to results for<jats:italic>Chlamydia trachomatis<\/jats:italic>, late shutdown of essential genes in<jats:italic>C. psittaci<\/jats:italic>was more comprehensive with IFN-\u03b3-induced persistence, which is probably due to the absence of a functional tryptophan synthesis operon.<\/jats:p>","DOI":"10.1128\/iai.01487-05","type":"journal-article","created":{"date-parts":[[2006,7,22]],"date-time":"2006-07-22T00:24:50Z","timestamp":1153527890000},"page":"4801-4808","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":94,"title":["Transcriptional Response Patterns of<i>Chlamydophila psittaci<\/i>in Different In Vitro Models of Persistent Infection"],"prefix":"10.1128","volume":"74","author":[{"given":"Stefanie","family":"Goellner","sequence":"first","affiliation":[{"name":"Institute of Bacterial Infections and Zoonoses"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Schubert","sequence":"additional","affiliation":[{"name":"Institute of Bacterial Infections and Zoonoses"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Liebler-Tenorio","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Hotzel","sequence":"additional","affiliation":[{"name":"Institute of Bacterial Infections and Zoonoses"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Peter","family":"Saluz","sequence":"additional","affiliation":[{"name":"Hans Knoell Institute for Natural Products Research, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Sachse","sequence":"additional","affiliation":[{"name":"Institute of Bacterial Infections and Zoonoses"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2001.00125.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.19.2.1223"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.3998"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.58.4.686-699.1994"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2535394100"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(96)80072-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.53.2.347-351.1986"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5423-5429.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6511-6518.2000"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1993.tb05958.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2442-2447.2001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203937200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01504-0"},{"key":"e_1_3_2_15_2","first-page":"313","volume":"9","year":"2002","unstructured":"Haranaga, S., H. 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