{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:28:23Z","timestamp":1790533703348,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Listeria monocytogenes<\/jats:named-content>\n            is a food-borne pathogen that can result in adverse pregnancy outcomes, such as stillbirth or premature delivery. The Mongolian gerbil was recently proposed as the most appropriate small-animal model of listeriosis due to its susceptibility to the same invasion pathways as humans. The objectives of this study were to investigate invasion and adverse pregnancy outcomes in gerbils orally exposed to\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            , to compare the dose-response data to those of other animal models, and to investigate differences in the responses of pregnant versus nonpregnant gerbils. Gerbils were orally exposed to 0 (control), 10\n            <jats:sup>3<\/jats:sup>\n            , 10\n            <jats:sup>5<\/jats:sup>\n            , 10\n            <jats:sup>7<\/jats:sup>\n            , or 10\n            <jats:sup>9<\/jats:sup>\n            CFU\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            in whipping cream.\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            was recovered in a dose-dependent manner from fecal samples, adult organs, and pregnancy-associated tissues. Dams exposed to 10\n            <jats:sup>9<\/jats:sup>\n            CFU had more invaded organs and higher concentrations of\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            in almost all organs than nonpregnant animals, though no differences in fecal shedding were seen between the two groups. Adverse pregnancy outcomes occurred only in the dams treated with 10\n            <jats:sup>9<\/jats:sup>\n            CFU. A 50% infectivity dose (ID\n            <jats:sub>50<\/jats:sub>\n            ) of 2.60 \u00d7 10\n            <jats:sup>6<\/jats:sup>\n            CFU for fetuses was calculated by fitting the data to a logistic model. Our results suggest that the 50% lethal dose (LD\n            <jats:sub>50<\/jats:sub>\n            ) falls within the range of 5 \u00d7 10\n            <jats:sup>6<\/jats:sup>\n            to 5 \u00d7 10\n            <jats:sup>8<\/jats:sup>\n            CFU. This range includes the guinea pig and nonhuman primate LD\n            <jats:sub>50<\/jats:sub>\n            s, but the observation that\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            -induced stillbirths can be seen in guinea pigs and primates exposed to lower doses than those at which stillbirths were seen in gerbils indicates that gerbils are not more sensitive to\n            <jats:named-content content-type=\"genus-species\">L. monocytogenes<\/jats:named-content>\n            invasion.\n          <\/jats:p>","DOI":"10.1128\/iai.01514-14","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T03:35:50Z","timestamp":1409024150000},"page":"4834-4841","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Dose Response of Listeria monocytogenes Invasion, Fetal Morbidity, and Fetal Mortality after Oral Challenge in Pregnant and Nonpregnant Mongolian Gerbils"],"prefix":"10.1128","volume":"82","author":[{"given":"Rebecca M.","family":"Roulo","sequence":"first","affiliation":[{"name":"Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian D.","family":"Fishburn","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayowa","family":"Amosu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Etchison","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Alice","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA"},{"name":"Center for Food Safety, University of Georgia, Griffin, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.09-1101p1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2011.035"},{"key":"e_1_3_3_4_2","unstructured":"Centers for Disease Control and Prevention. 4 December 2013. Listeriosis (Listeria infection). http:\/\/www.cdc.gov\/listeria\/."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200207000-00002"},{"key":"e_1_3_3_6_2","first-page":"776","article-title":"Listeria infection during pregnancy: a 10 year experience","volume":"4","author":"Benshushan A","year":"2002","unstructured":"BenshushanATsafrirAArbelRRahavGArielIRojanskyN. 2002. Listeria infection during pregnancy: a 10 year experience. Isr. Med. Assoc. J. 4:776\u2013780.","journal-title":"Isr. Med. Assoc. J."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.5.17703"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01146.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.10008"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900172"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1292"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.05.009"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00750.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00141-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000900"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-43-18"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3956"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00634.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-70.5.1122"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.489-497.2004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01570-06"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07303"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000732"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-380920-9.00052-3"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/laban.297"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01366-06"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.08.007"},{"key":"e_1_3_3_28_2","volume-title":"Interpretive summary no. 4","author":"Food and Agriculture Organization of United Nations and World Health Organization","year":"2004","unstructured":"Food and Agriculture Organization of United Nations and World Health Organization. 2004. Risk assessment of Listeria monocytogenes in ready-to-eat foods. Interpretive summary no. 4. World Health Organization. http:\/\/www.fao.org\/fileadmin\/templates\/agns\/pdf\/jemra\/mra4_en.pdf."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/430090"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00766.x"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01514-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01514-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:36:01Z","timestamp":1646483761000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01514-14"}},"subtitle":[],"editor":[{"given":"J. L.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1128\/IAI.01514-14"],"URL":"https:\/\/doi.org\/10.1128\/iai.01514-14","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2014-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}