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The transition between saprophytic and pathogenic life is mediated through complex regulatory pathways that modulate the expression of virulence factors. Here we examined the expression of\n            <jats:italic>inlJ<\/jats:italic>\n            , a recently identified gene encoding a protein of the LPXTG-internalin family and involved in pathogenesis. We show that\n            <jats:italic>inlJ<\/jats:italic>\n            expression is controlled neither by the major listerial regulator of virulence genes, PrfA, nor by AxyR, a putative AraC regulator encoded by a gene adjacent to\n            <jats:italic>inlJ<\/jats:italic>\n            and divergently transcribed. The InlJ protein is not produced by bacteria grown in vitro in brain heart infusion medium or replicating in the cytosol of tissue-cultured cells. In contrast, it is efficiently produced and localized at the surface of bacteria present in the liver and blood of infected animals. Strikingly, the expression of\n            <jats:italic>inlJ<\/jats:italic>\n            by a heterologous promoter in\n            <jats:italic>L<\/jats:italic>\n            .\n            <jats:italic>monocytogenes<\/jats:italic>\n            or\n            <jats:italic>L<\/jats:italic>\n            .\n            <jats:italic>innocua<\/jats:italic>\n            promotes bacterial adherence to human cells in vitro. Taken together, these results strongly suggest that InlJ acts as a novel\n            <jats:italic>L<\/jats:italic>\n            .\n            <jats:italic>monocytogenes<\/jats:italic>\n            sortase-anchored adhesin specifically expressed during infection in vivo.\n          <\/jats:p>","DOI":"10.1128\/iai.01519-07","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T01:46:26Z","timestamp":1201571186000},"page":"1368-1378","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":84,"title":["The\n            <i>Listeria monocytogenes<\/i>\n            Virulence Factor InlJ Is Specifically Expressed In Vivo and Behaves as an Adhesin"],"prefix":"10.1128","volume":"76","author":[{"given":"Christophe","family":"Sabet","sequence":"first","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Toledo-Arana","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Personnic","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lecuit","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"},{"name":"Service des Maladies infectieuses et tropicales, Universite\u0301 Paris 5, Ho\u0302pital Necker-Enfants malades, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dubrac","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 de Biologie des Bacte\u0301ries pathoge\u0300nes a\u0300 Gram-positif, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Poupel","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 de Biologie des Bacte\u0301ries pathoge\u0300nes a\u0300 Gram-positif, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Gouin","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Nahori","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u0301le\u0300ne","family":"Bierne","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris F-75015, France"},{"name":"INRA, USC2020, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4463-4471.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.21.5826-5832.2002"},{"key":"e_1_3_2_4_2","first-page":"423","volume":"4","year":"2007","unstructured":"Bierne, H., and P. 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