{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:52:59Z","timestamp":1772815979465,"version":"3.50.1"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Vaccination with live attenuated\n            <jats:italic>Yersinia pestis<\/jats:italic>\n            confers protection against pneumonic plague but is not considered safe for general use. Subunit plague vaccines containing the\n            <jats:italic>Y. pestis<\/jats:italic>\n            F1 and LcrV proteins prime robust antibody responses but may not provide sufficient protection. To aid the development of a safe and effective plague vaccine, we are investigating roles for T cells during defense against\n            <jats:italic>Y. pestis<\/jats:italic>\n            infection. Here we demonstrate that vaccination of mice with live\n            <jats:italic>Y. pestis<\/jats:italic>\n            primes specific CD4 and CD8 T cells that, upon purification and direct transfer to nai\u0308ve mice, synergistically protect against lethal intranasal\n            <jats:italic>Y. pestis<\/jats:italic>\n            challenge. While not preventing extrapulmonary dissemination, the coadministered T cells promote bacterial clearance and reduce bacteremia. These observations strongly suggest that development of pneumonic plague vaccines should strive to prime both CD4 and CD8 T cells. Finally, we demonstrate that vaccination with live\n            <jats:italic>Y. pestis<\/jats:italic>\n            primes CD4 and CD8 T cells that respond to\n            <jats:italic>Y. pestis<\/jats:italic>\n            strains lacking the capacity to express F1, LcrV, and all pCD1\/pPCP-encoded proteins, suggesting that protective T cells likely recognize antigens distinct from those previously defined as targets for humoral immunity.\n          <\/jats:p>","DOI":"10.1128\/iai.01529-06","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T03:36:36Z","timestamp":1164166596000},"page":"878-885","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":69,"title":["Vaccination with Live\n            <i>Yersinia pestis<\/i>\n            Primes CD4 and CD8 T Cells That Synergistically Protect against Lethal Pulmonary\n            <i>Y. pestis<\/i>\n            Infection"],"prefix":"10.1128","volume":"75","author":[{"given":"Alexander V.","family":"Philipovskiy","sequence":"first","affiliation":[{"name":"Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"Smiley","sequence":"additional","affiliation":[{"name":"Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"54","volume":"27","year":"1956","unstructured":"Abramova, G. 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