{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:26:38Z","timestamp":1779931598516,"version":"3.53.1"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Bordetella pertussis<\/jats:italic>\n            , a causative agent of whooping cough, expresses BrkA, which confers serum resistance, but the closely related human pathogen that also causes whooping cough,\n            <jats:italic>Bordetella parapertussis<\/jats:italic>\n            , does not. Interestingly,\n            <jats:italic>B. parapertussis<\/jats:italic>\n            , but not\n            <jats:italic>B. pertussis<\/jats:italic>\n            , produces an O antigen, a factor shown in other models to confer serum resistance. Using a murine model of infection, we determined that O antigen contributes to the ability of\n            <jats:italic>B. parapertussis<\/jats:italic>\n            to colonize the respiratory tract during the first week of infection, but not thereafter. Interestingly, an O antigen-deficient strain of\n            <jats:italic>B. parapertussis<\/jats:italic>\n            was not defective in colonizing mice lacking the complement cascade. O antigen prevented both complement component C3 deposition on the surface and complement-mediated killing of\n            <jats:italic>B. parapertussis<\/jats:italic>\n            . In addition, O antigen was required for\n            <jats:italic>B. parapertussis<\/jats:italic>\n            to systemically spread in complement-sufficient mice, but not complement-deficient mice. These data indicate that O antigen enables\n            <jats:italic>B. parapertussis<\/jats:italic>\n            to efficiently colonize the lower respiratory tract by protecting against complement-mediated control and clearance.\n          <\/jats:p>","DOI":"10.1128\/iai.01629-07","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T04:25:35Z","timestamp":1203481535000},"page":"1774-1780","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["O Antigen Protects\n            <i>Bordetella parapertussis<\/i>\n            from Complement"],"prefix":"10.1128","volume":"76","author":[{"given":"Elizabeth M.","family":"Goebel","sequence":"first","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802"},{"name":"Graduate Program in Immunology and Infectious 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