{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:51:03Z","timestamp":1762865463231},"reference-count":24,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The virulence of SCC\n            <jats:italic>mec<\/jats:italic>\n            type IV hospital-acquired methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (MRSA) clinical isolates belonging to the major sequence type 8 (ST8 [Lyon clone]) and to a minor upcoming clone, ST5, was compared with that of methicillin-susceptible\n            <jats:italic>S. aureus<\/jats:italic>\n            (MSSA) isolates of matching sequence types. In vitro adhesion to human airway epithelial cells (HAECs) as an indicator of dissemination and mortality in a murine sepsis model as an indicator of virulence were evaluated. Ten MRSA isolates and 8 MSSA isolates of ST8 and 8 MRSA isolates and 8 MSSA isolates of ST5 were characterized with respect to multilocus sequence type;\n            <jats:italic>agr, spa<\/jats:italic>\n            , and capsule typing; in vitro doubling time; toxin and adhesin gene profiles; and adherence to HAECs. Adherence was significantly lower in the MRSA ST5 group than in the ST8 groups. Infections with MRSA and MSSA isolates ST8 and ST5 were compared. No change in virulence related to the presence of SCC\n            <jats:italic>mec<\/jats:italic>\n            was observed, since ST8 but not ST5 caused a significantly lower mortality in its presence. Despite their similar genetic backgrounds, individual clonal MRSA and MSSA isolates were heterogeneous in adherence and virulence. No one of these specific virulence factors determined in vitro was related to mouse mortality. In conclusion, in a bacteremic model, mortality was dependent on the ST and was differentially modulated by SCC\n            <jats:italic>mec<\/jats:italic>\n            ; within an ST, clonality was not associated with a homogenous outcome.\n          <\/jats:p>","DOI":"10.1128\/iai.01697-07","type":"journal-article","created":{"date-parts":[[2008,9,9]],"date-time":"2008-09-09T00:33:56Z","timestamp":1220920436000},"page":"5133-5138","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of Adhesion and Virulence of Two Predominant Hospital-Acquired Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            Clones and Clonal Methicillin-Susceptible\n            <i>S. aureus<\/i>\n            Isolates"],"prefix":"10.1128","volume":"76","author":[{"given":"Hatice","family":"Karauzum","sequence":"first","affiliation":[{"name":"Division of Infection Biology, Department of Biomedicine, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Ferry","sequence":"additional","affiliation":[{"name":"INSERM, U851, Lyon, F-69008 France"},{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Faculte\u0301 Laennec, 7 rue Guillaume Paradin, Lyon, F-69008 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"de Bentzmann","sequence":"additional","affiliation":[{"name":"Unite\u0301 Propre de Recherche 9027, Laboratoire d'Inge\u0301nierie des Syste\u0300mes Macromole\u0301culaires, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u0301rard","family":"Lina","sequence":"additional","affiliation":[{"name":"INSERM, U851, Lyon, F-69008 France"},{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Faculte\u0301 Laennec, 7 rue Guillaume Paradin, Lyon, F-69008 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miche\u0300le","family":"Bes","sequence":"additional","affiliation":[{"name":"INSERM, U851, Lyon, F-69008 France"},{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Faculte\u0301 Laennec, 7 rue Guillaume Paradin, Lyon, F-69008 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franc\u0327ois","family":"Vandenesch","sequence":"additional","affiliation":[{"name":"INSERM, U851, Lyon, F-69008 France"},{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Faculte\u0301 Laennec, 7 rue Guillaume Paradin, Lyon, F-69008 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Schmaler","sequence":"additional","affiliation":[{"name":"Division of Infection Biology, Department of Biomedicine, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Berger-Ba\u0308chi","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Etienne","sequence":"additional","affiliation":[{"name":"INSERM, U851, Lyon, F-69008 France"},{"name":"Universite\u0301 Lyon 1, Centre National de Re\u0301fe\u0301rence des Staphylocoques, Faculte\u0301 Laennec, 7 rue Guillaume Paradin, Lyon, F-69008 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Landmann","sequence":"additional","affiliation":[{"name":"Division of Infection Biology, Department of Biomedicine, University Hospital, Basel, 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