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In this work, we identified a cross-reactive<jats:italic>S. mansoni<\/jats:italic>gene product, referred to as SmLRR, that seems to belong to the leucine-rich repeat protein family. Comparative analysis of SmLRR revealed 57% similarity with a putative gene product encoded in the<jats:italic>P. falciparum<\/jats:italic>genome. Antibodies to SmLRR were found in experimental infections and in both<jats:italic>S. mansoni<\/jats:italic>- and<jats:italic>P. falciparum<\/jats:italic>-infected individuals. Correlative analysis of human anti-SmLRR responses in Kenya and Uganda suggested that malaria and schistosomiasis drive the immunoglobulin G3 (IgG3) and IgG4 isotypes, respectively, against SmLRR, suggesting that there is differential regulation of cross-reactive isotypes depending on the infection. In addition, the levels of anti-SmLRR IgG4, but not the levels of IgG3, correlated positively with the intensity of<jats:italic>S. mansoni<\/jats:italic>infection.<\/jats:p>","DOI":"10.1128\/iai.01724-05","type":"journal-article","created":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T23:52:41Z","timestamp":1148082761000},"page":"3347-3354","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Identification of a Novel Antigen of<i>Schistosoma mansoni<\/i>Shared with<i>Plasmodium falciparum<\/i>and Evaluation of Different Cross-Reactive Antibody Subclasses Induced by Human Schistosomiasis and Malaria"],"prefix":"10.1128","volume":"74","author":[{"given":"Christine","family":"Pierrot","sequence":"first","affiliation":[{"name":"Unite\u0301 Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shona","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u0301le\u0300ne","family":"Lallet","sequence":"additional","affiliation":[{"name":"Unite\u0301 Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Lafitte","sequence":"additional","affiliation":[{"name":"Unite\u0301 Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Daher","sequence":"additional","affiliation":[{"name":"Unite\u0301 Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Capron","sequence":"additional","affiliation":[{"name":"Unite\u0301 Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dunne","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Khalife","sequence":"additional","affiliation":[{"name":"Unite\u0301 Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(03)00176-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-13"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.409"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60486-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139209069383"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180119"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-186.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.692"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(90)90021-P"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/349243a0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5167-5174.1998"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.4.1432-1433.1996"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(02)52014-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00535.x"},{"key":"e_1_3_2_16_2","first-page":"397","volume":"14","year":"1972","unstructured":"Katz, N., A. 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