{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:21:45Z","timestamp":1790695305353,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Yersiniosis is a human disease caused by the bacterium\n            <jats:named-content content-type=\"genus-species\">Yersinia pseudotuberculosis<\/jats:named-content>\n            or\n            <jats:named-content content-type=\"genus-species\">Yersinia enterocolitica<\/jats:named-content>\n            . The infection is usually resolved but can lead to postinfectious sequelae, including reactive arthritis and erythema nodosum. The commonly used\n            <jats:named-content content-type=\"genus-species\">Yersinia<\/jats:named-content>\n            mouse infection model mimics acute infection in humans to some extent but leads to systemic infection and eventual death. Here, we analyzed sublethal infection doses of\n            <jats:named-content content-type=\"genus-species\">Y. pseudotuberculosis<\/jats:named-content>\n            in mice in real time using bioluminescent imaging and found that infections using these lower doses result in extended periods of asymptomatic infections in a fraction of mice. In a search for the site for bacterial persistence, we found that the cecum was the primary colonization site and was the site where the organism resided during a 115-day infection period. Persistent infection was accompanied by sustained fecal shedding of cultivable bacteria. Cecal patches were identified as the primary site for cecal colonization during persistence.\n            <jats:named-content content-type=\"genus-species\">Y. pseudotuberculosis<\/jats:named-content>\n            bacteria were present in inflammatory lesions, in localized foci, or as single cells and also in neutrophil exudates in the cecal lumen. The chronically colonized cecum may serve as a reservoir for dissemination of infection to extraintestinal sites, and a chronic inflammatory state may trigger the onset of postinfectious sequelae. This novel mouse model for bacterial persistence in cecum has potential as an investigative tool to unveil a deeper understanding of bacterial adaptation and host immune defense mechanisms during persistent infection.\n          <\/jats:p>","DOI":"10.1128\/iai.01793-14","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T06:33:39Z","timestamp":1401777219000},"page":"3471-3482","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Colonization of Cecum Is Important for Development of Persistent Infection by Yersinia pseudotuberculosis"],"prefix":"10.1128","volume":"82","author":[{"given":"Anna","family":"Fahlgren","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"Avican","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Westermark","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Nordfelth","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"F\u00e4llman","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research (UCMR), Ume\u00e5 University, Ume\u00e5, Sweden"},{"name":"Laboratory for Molecular Infection Medicine Sweden, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)00038-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro955"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.23987"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323879"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/182051"},{"key":"e_1_3_3_7_2","first-page":"201","article-title":"Infectious ileocecitis\u2014appendicitis mimicking syndrome","volume":"106","author":"Zganjer M","year":"2005","unstructured":"ZganjerMRoicGCizmicAPajicA. 2005. 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