{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:22:26Z","timestamp":1782847346553,"version":"3.54.5"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Burkholderia pseudomallei<\/jats:named-content>\n            , the etiological agent for melioidosis, is an important cause of community-acquired sepsis in northern Australia and northeast Thailand. Due to the rapid dissemination of disease in acute melioidosis, we hypothesized that dendritic cells (DC) could act as a vehicle for dissemination of\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            . Therefore, this study investigated the effect of\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            infection on DC migration capacity and whether migration of DC enabled transportation of\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            from the site of infection.\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            stimulated significantly increased migration of bone marrow-derived DC (BMDC), both\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            , compared to uninfected BMDC. Furthermore, migration of BMDC enabled significantly increased\n            <jats:italic>in vitro<\/jats:italic>\n            trafficking of\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            dissemination of\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            to secondary lymphoid organs and lungs of C57BL\/6 mice. DC within the footpad infection site of C57BL\/6 mice also internalized\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            and facilitated dissemination. Although DC have previously been shown to kill intracellular\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            <jats:italic>in vitro<\/jats:italic>\n            , the findings of this study demonstrate that\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            -infected DC facilitate the systemic spread of this pathogen.\n          <\/jats:p>","DOI":"10.1128\/iai.01880-14","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T04:03:27Z","timestamp":1406606607000},"page":"4233-4240","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Migration of Dendritic Cells Facilitates Systemic Dissemination of Burkholderia pseudomallei"],"prefix":"10.1128","volume":"82","author":[{"given":"Natasha 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