{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:27:39Z","timestamp":1772162859256,"version":"3.50.1"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Burkholderia mallei<\/jats:italic>\n is a highly infectious gram-negative pathogen and is the causative agent of human and animal glanders. By generating polar mutations (disruption of\n bsaQ<\/jats:italic>\n and\n bsaZ<\/jats:italic>\n ) in the\n B. mallei<\/jats:italic>\n ATCC 23344 animal pathogen-like type III secretion system (TTS), we demonstrate that this bacterial protein delivery system is required for intracellular growth of\n B. mallei<\/jats:italic>\n in J774.2 cells, formation of macrophage membrane protrusions, actin polymerization, and phagosomal escape. These findings suggest that TTS plays a role in the intracellular trafficking of\n B. mallei<\/jats:italic>\n and may facilitate cell-to-cell spread via actin-based motility.\n <\/jats:p>","DOI":"10.1128\/iai.01939-05","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T19:10:29Z","timestamp":1150917029000},"page":"4349-4353","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["The Animal Pathogen-Like Type III Secretion System Is Required for the Intracellular Survival of\n Burkholderia mallei<\/i>\n within J774.2 Macrophages"],"prefix":"10.1128","volume":"74","author":[{"given":"Wilson J.","family":"Ribot","sequence":"first","affiliation":[{"name":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky L.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3702-3713.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.735"},{"key":"e_1_3_2_4_2","first-page":"209","year":"2004","unstructured":"DeShazer, D., and D. Waag. 2004. Glanders: new insights into an old disease, p. 209-237. In L. Lindler, F. Lebeda, and G. W. Korch (ed.), Biological weapons defense: infectious diseases and counterbioterrorism. The Humana Press, Inc., Totowa, N.J.","journal-title":"Biological weapons defense: infectious diseases and counterbioterrorism"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2000.0430"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.53"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.2.379-433.1998"},{"key":"e_1_3_2_8_2","first-page":"115","volume":"55","year":"1947","unstructured":"Miller, W. R., L. Pannell, L. Cravitz, W. A. Tanner, and T. Rosebury. 1947. Studies on certain biological characteristics of Malleomyces mallei and Malleomyces pseudomallei. J. Bacteriol.55:115-126.","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.22.7857-7862.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.16.4992-4996.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27146-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03190.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.18.6556-6560.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.10.017"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.1150-1154.2004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2004.10.045"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01939-05","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.01939-05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:38:06Z","timestamp":1646444286000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.01939-05"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1128\/IAI.01939-05"],"URL":"https:\/\/doi.org\/10.1128\/iai.01939-05","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1040678.489696","asserted-by":"object"}]},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"2005-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}