{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:49:04Z","timestamp":1793321344756,"version":"4.5.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            siglecs are a family of sialic-acid binding immunoglobulin-like lectins mostly expressed by cells of the immune system that have the potential to interact with sialylated glycans expressed not only on host cells but also on certain pathogens.\n            <jats:italic>Campylobacter jejuni<\/jats:italic>\n            is a common pathogen of humans that expresses surface lipooligosaccharides (LOS) that can be modified with ganglioside-like terminal structures in the core oligosaccharides. In this study, we examined the interaction of 10 siglecs with LOS purified from four different\n            <jats:italic>C. jejuni<\/jats:italic>\n            isolates expressing GM1-like, GD1a-like, GD3-like, and GT1a-like oligosaccharides. Of all siglecs examined, only Siglec-7 exhibited specific, sialic acid-dependent interactions with\n            <jats:italic>C. jejuni<\/jats:italic>\n            LOS in solid-phase binding assays. Binding was especially prominent with LOS from the HS:19(GM1\n            <jats:sup>+<\/jats:sup>\n            GT1a\n            <jats:sup>+<\/jats:sup>\n            ) isolate, with weaker binding with LOS from the HS:19(GD3\n            <jats:sup>+<\/jats:sup>\n            ) isolate. Binding of Siglec-7 was also observed with intact bacteria expressing these LOS structures. Specific binding of HS:19(GM1\n            <jats:sup>+<\/jats:sup>\n            GT1a\n            <jats:sup>+<\/jats:sup>\n            ) bacteria was demonstrated with Siglec-7 expressed on transfected Chinese hamster ovary cells and with peripheral blood leukocytes, among which HS:19(GM1\n            <jats:sup>+<\/jats:sup>\n            GT1a\n            <jats:sup>+<\/jats:sup>\n            ) bacteria bound selectively to both natural killer cells and monocytes which naturally express Siglec-7. These results raise the possibility that, in addition to their role in generating autoimmune antibody responses,\n            <jats:italic>C. jejuni<\/jats:italic>\n            LOS could interact with Siglec-7 expressed by leukocytes, modulate the host-pathogen interaction, and contribute to the clinical outcome and the development of secondary complications such as Guillain-Barre\u0301 syndrome.\n          <\/jats:p>","DOI":"10.1128\/iai.02094-05","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T23:10:29Z","timestamp":1150931429000},"page":"4133-4141","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":119,"title":["Sialic Acid-Binding Immunoglobulin-Like Lectin 7 Mediates Selective Recognition of Sialylated Glycans Expressed on\n            <i>Campylobacter jejuni<\/i>\n            Lipooligosaccharides"],"prefix":"10.1128","volume":"74","author":[{"given":"Tony","family":"Avril","sequence":"first","affiliation":[{"name":"Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, University of Glasgow, Southern General Hospital, Glasgow G51 4TF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh J.","family":"Willison","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, University of Glasgow, Southern General Hospital, Glasgow G51 4TF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Crocker","sequence":"additional","affiliation":[{"name":"Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United 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