{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:27:36Z","timestamp":1777062456425,"version":"3.51.4"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Streptococcus mutans<\/jats:named-content>\n            , a pathogen responsible for dental caries, is occasionally isolated from the blood of patients with bacteremia and infective endocarditis (IE). Our previous study demonstrated that serotype\n            <jats:italic>k<\/jats:italic>\n            -specific bacterial DNA is frequently detected in\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            -positive heart valve specimens extirpated from IE patients. However, the reason for this frequent detection remains unknown. In the present study, we analyzed the virulence of IE from\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            strains, focusing on the characterization of serotype\n            <jats:italic>k<\/jats:italic>\n            strains, most of which are positive for the 120-kDa cell surface collagen-binding protein Cbm and negative for the 190-kDa protein antigen (PA) known as SpaP, P1, antigen I\/II, and other designations. Fibrinogen-binding assays were performed with 85 clinical strains classified by Cbm and PA expression levels. The Cbm\n            <jats:sup>+<\/jats:sup>\n            \/PA\n            <jats:sup>\u2212<\/jats:sup>\n            group strains had significantly higher fibrinogen-binding rates than the other groups. Analysis of platelet aggregation revealed that SA31, a Cbm\n            <jats:sup>+<\/jats:sup>\n            \/PA\n            <jats:sup>\u2212<\/jats:sup>\n            strain, induced an increased level of aggregation in the presence of fibrinogen, while negligible aggregation was induced by the Cbm-defective isogenic mutant SA31CBD. A rat IE model with an artificial impairment of the aortic valve created using a catheter showed that extirpated heart valves in the SA31 group displayed a prominent vegetation mass not seen in those in the SA31CBD group. These findings could explain why Cbm\n            <jats:sup>+<\/jats:sup>\n            \/PA\n            <jats:sup>\u2212<\/jats:sup>\n            strains are highly virulent and are related to the development of IE, and the findings could also explain the frequent detection of serotype\n            <jats:italic>k<\/jats:italic>\n            DNA in\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            -positive heart valve clinical specimens.\n          <\/jats:p>","DOI":"10.1128\/iai.02164-14","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T07:41:35Z","timestamp":1412667695000},"page":"5223-5234","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Contribution of the Interaction of Streptococcus mutans Serotype\n            <i>k<\/i>\n            Strains with Fibrinogen to the Pathogenicity of Infective Endocarditis"],"prefix":"10.1128","volume":"82","author":[{"given":"Ryota","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Otsugu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Division of Oral Infections and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, 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