{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:28:52Z","timestamp":1766136532774},"reference-count":73,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Streptococcus suis<\/jats:named-content>\n            serotype 2 is an extracellular encapsulated bacterium that causes severe septicemia and meningitis in swine and humans. Albeit crucial in the fight against encapsulated bacteria, the nature of the capsular polysaccharide (CPS)-specific antibody (Ab) response during\n            <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n            type 2 infection is unknown. We compared for the first time the features of CPS-specific versus protein-specific Ab responses during experimental infections with live virulent\n            <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n            type 2 in mice. The primary protein-specific Ab response was dominated by both type 1 and 2 IgG subclasses, whereas IgM titers were more modest. The secondary protein-specific Ab response showed all of the features of a memory response with faster kinetics and boosted the titers of all Ig isotypes. In contrast, the primary CPS-specific Ab response was either inexistent or had titers only slightly higher than those in noninfected animals and was essentially composed of IgM. A poor CPS-specific memory response was observed, with only a moderate boost in IgM titers and no IgG. Both protein- and CPS-specific Ab responses were Toll-like receptor 2 independent. By using\n            <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n            type 2 strains of European or North American origin, the poor CPS-specific Ab response was demonstrated to be independent of the genotypic\/phenotypic diversity of the strain within serotype 2. Finally, the CPS-specific Ab response was also impaired and lacked isotype switching in\n            <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n            -infected pigs, the natural host of the bacterium. The better resistance of preinfected animals to reinfection with the same strain of\n            <jats:named-content content-type=\"genus-species\">S. suis<\/jats:named-content>\n            type 2 might thus more likely be related to the development of a protein rather than CPS Ab response.\n          <\/jats:p>","DOI":"10.1128\/iai.02427-14","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T05:20:18Z","timestamp":1415683218000},"page":"441-453","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Antibody Response Specific to the Capsular Polysaccharide Is Impaired in Streptococcus suis Serotype 2-Infected Animals"],"prefix":"10.1128","volume":"83","author":[{"given":"Cynthia","family":"Calzas","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lemire","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gael","family":"Auray","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Gerdts","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Organization (VIDO) and Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Segura","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/594371"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2014.45"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.149"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir415"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1998.tb01165.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-42-72"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1139\/O09-170"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.59.4.591-603.1995"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37652005000200009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.06.040188.001343"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111212"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01362.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.1.34"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00142-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00046-07"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.003255"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.298-307.2005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101446"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200132"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900238"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)30963-9"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(89)90009-1"},{"key":"e_1_3_3_25_2","first-page":"49","article-title":"Evaluation of the antibody response in pigs vaccinated against Streptococcus suis capsular type 2 using a double-antibody sandwich enzyme-linked immunosorbent assay","volume":"58","author":"Blouin C","year":"1994","unstructured":"Blouin C, Higgins R, Gottschalk M, Simard J. 1994. 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