{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:30Z","timestamp":1791308850234,"version":"4.3.1"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            is part of the normal commensal microbiota of mucosal surfaces in a large percentage of the human population. However, perturbations of the host's immune response or bacterial microbiota have been shown to predispose individuals to the development of opportunistic\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            infections. It was recently discovered that a defect in the chemokine receptor CX\n            <jats:sub>3<\/jats:sub>\n            CR1 increases susceptibility of mice and humans to systemic candidiasis. However, whether CX\n            <jats:sub>3<\/jats:sub>\n            CR1 confers protection against mucosal\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            infection has not been investigated. Using two different mouse models, we found that Cx3cr1 is dispensable for the induction of interleukin 17A (IL-17A), IL-22, and IL-23 in the tongue after infection, as well as for the clearance of mucosal candidiasis from the tongue or lower gastrointestinal (GI) tract colonization. Furthermore, the dysfunctional human CX\n            <jats:sub>3<\/jats:sub>\n            CR1 allele\n            <jats:italic>\n              CX\n              <jats:sub>3<\/jats:sub>\n              CR1-M280\n            <\/jats:italic>\n            was not associated with development of recurrent vulvovaginal candidiasis (RVVC) in women. Taken together, these data indicate that CX\n            <jats:sub>3<\/jats:sub>\n            CR1 is not essential for protection of the host against mucosal candidiasis, underscoring the dependence on different mammalian immune factors for control of mucosal versus systemic\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/iai.02604-14","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T08:38:05Z","timestamp":1419928685000},"page":"958-965","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["CX\n            <sub>3<\/sub>\n            CR1 Is Dispensable for Control of Mucosal Candida albicans Infections in Mice and Humans"],"prefix":"10.1128","volume":"83","author":[{"given":"Timothy J.","family":"Break","sequence":"first","affiliation":[{"name":"Fungal Pathogenesis 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