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Type I IFNs and B cells critically contribute to immunity to\n            <jats:named-content content-type=\"genus-species\">Pneumocystis<\/jats:named-content>\n            lung infection. We recently also identified B cells as supporters of on-demand hematopoiesis following\n            <jats:named-content content-type=\"genus-species\">Pneumocystis<\/jats:named-content>\n            infection that would otherwise be hampered due to systemic immune effects initiated in the context of a defective type I IFN system. While studying the role of type I IFNs in immunity to\n            <jats:named-content content-type=\"genus-species\">Pneumocystis<\/jats:named-content>\n            infection, we discovered that mice lacking both lymphocytes and type I IFN receptor (IFrag\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ) developed progressive bone marrow failure following infection, while lymphocyte-competent type I IFN receptor-deficient mice (IFNAR\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ) showed transient bone marrow depression and extramedullary hematopoiesis. Lymphocyte reconstitution of lymphocyte-deficient IFrag\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice pointed to B cells as a key player in bone marrow protection. Here we define how B cells protect on-demand hematopoiesis following\n            <jats:named-content content-type=\"genus-species\">Pneumocysti<\/jats:named-content>\n            s lung infection in our model. We demonstrate that adoptive transfer of B cells into IFrag\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice protects early hematopoietic progenitor activity during systemic responses to\n            <jats:named-content content-type=\"genus-species\">Pneumocystis<\/jats:named-content>\n            infection, thus promoting replenishment of depleted bone marrow cells. This activity is independent of CD4\n            <jats:sup>+<\/jats:sup>\n            T cell help and B cell receptor specificity and does not require B cell migration to bone marrow. Furthermore, we show that B cells protect on-demand hematopoiesis in part by induction of interleukin-10 (IL-10)- and IL-27-mediated mechanisms. Thus, our data demonstrate an important immune modulatory role of B cells during\n            <jats:named-content content-type=\"genus-species\">Pneumocystis<\/jats:named-content>\n            lung infection that complement the modulatory role of type I IFNs to prevent systemic complications.\n          <\/jats:p>","DOI":"10.1128\/iai.02639-14","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T08:05:56Z","timestamp":1417507556000},"page":"743-758","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["B Cells Modulate Systemic Responses to Pneumocystis murina Lung Infection and Protect On-Demand Hematopoiesis via T Cell-Independent Innate Mechanisms when Type I Interferon Signaling Is Absent"],"prefix":"10.1128","volume":"83","author":[{"given":"Teri R.","family":"Hoyt","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Dobrinen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kochetkova","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Meissner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134335"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1621"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.03.027"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/339548"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399405010203"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1063852"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0477"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0453-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2475-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(08)70173-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4472"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.7.594"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00013-12"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/319340"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01712-09"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-094OC"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/313521"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1997.tb05743.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-47-4-329"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/518989"},{"key":"e_1_3_2_22_2","first-page":"121","article-title":"Pneumocystis jiroveci infection in immunocompetent patients with pulmonary disorders, in Portugal","volume":"19","author":"Matos O","year":"2006","unstructured":"Matos O, Costa MC, Correia I, Monteiro P, Vieira JR, Soares J, Bonnet M, Esteves F, Antunes F. 2006. 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