{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:28:34Z","timestamp":1790882914274,"version":"4.1.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The viscoelastic mucus layer of gastrointestinal tracts is a host defense barrier that a successful enteric pathogen, such as\n            <jats:named-content content-type=\"genus-species\">Vibrio cholerae<\/jats:named-content>\n            , must circumvent.\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            , the causative agent of cholera, is able to penetrate the mucosa and colonize the epithelial surface of the small intestine. In this study, we found that mucin, the major component of mucus, promoted\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            movement on semisolid medium and in liquid medium. A genome-wide screen revealed that\n            <jats:named-content content-type=\"genus-species\">Vibrio<\/jats:named-content>\n            polysaccharide (VPS) production was inversely correlated with mucin-enhanced motility. Mucin adhesion assays indicated that VPS bound to mucin. Moreover, we found that\n            <jats:italic>vps<\/jats:italic>\n            expression was reduced upon exposure to mucin. In an infant mouse colonization model, mutants that overexpressed VPS colonized less effectively than wild-type strains in more distal intestinal regions. These results suggest that\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            is able to sense mucosal signals and modulate\n            <jats:italic>vps<\/jats:italic>\n            expression accordingly so as to promote fast motion in mucus, thus allowing for rapid spread throughout the intestines.\n          <\/jats:p>","DOI":"10.1128\/iai.02841-14","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T04:06:37Z","timestamp":1420517197000},"page":"1114-1121","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Vibrio cholerae Represses Polysaccharide Synthesis To Promote Motility in Mucosa"],"prefix":"10.1128","volume":"83","author":[{"given":"Zhenyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Microbiology, Nanjing Agricultural University, Nanjing, China"},{"name":"State Key Laboratory 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