{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:16:37Z","timestamp":1777072597681,"version":"3.51.4"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Tick-borne spotted fever group (SFG)\n            <jats:named-content content-type=\"genus-species\">Rickettsia<\/jats:named-content>\n            species are obligate intracellular bacteria capable of infecting both vertebrate and invertebrate host cells, an essential process for subsequent bacterial survival in distinct hosts. The host cell signaling molecules involved in the uptake of\n            <jats:named-content content-type=\"genus-species\">Rickettsia<\/jats:named-content>\n            into mammalian and\n            <jats:named-content content-type=\"genus-species\">Drosophila<\/jats:named-content>\n            cells have been identified; however, invasion into tick cells is understudied. Considering the movement of SFG\n            <jats:named-content content-type=\"genus-species\">Rickettsia<\/jats:named-content>\n            between vertebrate and invertebrate hosts, the hypothesis is that conserved mechanisms are utilized for host cell invasion. The current study employed biochemical inhibition assays to determine the tick proteins involved in\n            <jats:named-content content-type=\"genus-species\">Rickettsia montanensis<\/jats:named-content>\n            infection of tick-derived cells from a natural host,\n            <jats:named-content content-type=\"genus-species\">Dermacentor variabilis<\/jats:named-content>\n            . The results revealed several tick proteins important for rickettsial invasion, including actin filaments, actin-related protein 2\/3 complex, phosphatidylinositol-3\u2032-kinase, protein tyrosine kinases (PTKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1, and neural Wiskott-Aldrich syndrome protein. Delineating the molecular mechanisms of rickettsial infection is critical to a thorough understanding of rickettsial transmission in tick populations and the ecology of tick-borne rickettsial diseases.\n          <\/jats:p>","DOI":"10.1128\/iai.02888-14","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T08:38:05Z","timestamp":1419928685000},"page":"1048-1055","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Identification of Host Proteins Involved in Rickettsial Invasion of Tick Cells"],"prefix":"10.1128","volume":"83","author":[{"given":"Natthida","family":"Petchampai","sequence":"first","affiliation":[{"name":"Vector-borne Disease Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyanate","family":"Sunyakumthorn","sequence":"additional","affiliation":[{"name":"Vector-borne Disease Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaikhushroo H.","family":"Banajee","sequence":"additional","affiliation":[{"name":"Vector-borne Disease Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria I.","family":"Verhoeve","sequence":"additional","affiliation":[{"name":"Vector-borne Disease Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Kearney","sequence":"additional","affiliation":[{"name":"Vector-borne Disease Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Macaluso","sequence":"additional","affiliation":[{"name":"Vector-borne Disease Laboratories, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44402"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1866"},{"key":"e_1_3_3_4_2","first-page":"154","volume-title":"Intracellular pathogens II: Rickettsiales","author":"Welch MD","year":"2012","unstructured":"Welch MD, Reed SC, Haglund CM. 2012. 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