{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:23:45Z","timestamp":1790663025428,"version":"4.1.0"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Tryptophan-rich proteins play important biological functions for the\n            <jats:named-content content-type=\"genus-species\">Plasmodium<\/jats:named-content>\n            parasite.\n            <jats:named-content content-type=\"genus-species\">Plasmodium vivax<\/jats:named-content>\n            contains remarkably large numbers of such proteins belonging to the \u201cPv-fam-a\u201d family that need to be characterized. Earlier, we reported the presence of memory T cells and naturally acquired antibodies against 15 of these proteins in\n            <jats:named-content content-type=\"genus-species\">P. vivax<\/jats:named-content>\n            malaria-exposed individuals (M. Zeeshan, H. Bora, and Y. D. Sharma, J Infect Dis\n            <jats:bold>207:<\/jats:bold>\n            175\u2013185, 2013,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1093\/infdis\/jis650\">http:\/\/dx.doi.org\/10.1093\/infdis\/jis650<\/jats:ext-link>\n            ). Here, we sought to characterize and ascertain the cross talk between effector responses of T and B cells in malarial patients against all Pv-fam-a family proteins. Therefore, we expressed the remaining 21 of these proteins in\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            and studied the humoral and cellular immune responses based on the same parameters used in our previous study. Naturally acquired IgG antibodies were detected against all 21 antigens in\n            <jats:named-content content-type=\"genus-species\">P. vivax<\/jats:named-content>\n            patient sera (37.7 to 94.4% seropositivity). These antigens were able to activate the lymphocytes of\n            <jats:named-content content-type=\"genus-species\">P. vivax<\/jats:named-content>\n            -exposed individuals, and the activated CD4\n            <jats:sup>+<\/jats:sup>\n            T lymphocytes produced higher levels of Th1 (interleukin-2 [IL-2] and gamma interferon [IFN-\u03b3]) and Th2 (IL-4 and IL-10) cytokines than the healthy controls, but the response was Th2 biased. The combined results of present and previous studies seem to suggest a striking link between induction of the CD4\n            <jats:sup>+<\/jats:sup>\n            T cell response and naturally acquired antibodies against all 36 proteins of the Pv-fam-a family, the majority of them having conserved sequences in the parasite population. Further work is required to utilize this information to develop immunotherapeutic treatments for this disease.\n          <\/jats:p>","DOI":"10.1128\/iai.03095-14","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T03:13:25Z","timestamp":1425352405000},"page":"2018-2029","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["CD4\n            <sup>+<\/sup>\n            T Cell Response Correlates with Naturally Acquired Antibodies against Plasmodium vivax Tryptophan-Rich Antigens"],"prefix":"10.1128","volume":"83","author":[{"given":"Mohammad","family":"Zeeshan","sequence":"first","affiliation":[{"name":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagya D.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.14.5484"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.05.015"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.01.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001221"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00344-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.10.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6354-6357.2003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(97)00173-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.05.059"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00252-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.8.3138-3145.1997"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.05.008"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.01.020"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.07.004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2004.06.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00677-07"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050754"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00370-X"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-014-1428-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.675-680.1999"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.10.042"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807404105"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu558"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis650"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056061"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2370-z"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-186"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-155"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00172-08"},{"key":"e_1_3_3_31_2","first-page":"EIM14","article-title":"Erythrophagocytosis by peripheral monocytes in Plasmodium falciparum malaria","volume":"87","author":"La Raja M","year":"2002","unstructured":"La Raja M. 2002. 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