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Despite the peril associated with\n            <jats:named-content content-type=\"genus-species\">Cronobacter<\/jats:named-content>\n            infection, the mechanisms of pathogenesis are still being unraveled. Hfq, which is known as an RNA chaperone, participates in the interaction with bacterial small RNAs (sRNAs) to regulate posttranscriptionally the expression of various genes. Recent studies have demonstrated that Hfq contributes to the pathogenesis of numerous species of bacteria, and its roles are varied between bacterial species. Here, we tried to elucidate the role of Hfq in\n            <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n            virulence. In the absence of\n            <jats:italic>hfq<\/jats:italic>\n            ,\n            <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n            was highly attenuated in dissemination\n            <jats:italic>in vivo<\/jats:italic>\n            , showed defects in invasion (3-fold) into animal cells and survival (10\n            <jats:sup>3<\/jats:sup>\n            -fold) within host cells, and exhibited low resistance to hydrogen peroxide (10\n            <jats:sup>2<\/jats:sup>\n            -fold). Remarkably, the loss of\n            <jats:italic>hfq<\/jats:italic>\n            led to hypermotility on soft agar, which is contrary to what has been observed in other pathogenic bacteria. The hyperflagellated bacteria were likely to be attributable to the increased transcription of genes associated with flagellar biosynthesis in a strain lacking\n            <jats:italic>hfq<\/jats:italic>\n            . Together, these data strongly suggest that\n            <jats:italic>hfq<\/jats:italic>\n            plays important roles in the virulence of\n            <jats:named-content content-type=\"genus-species\">C. sakazakii<\/jats:named-content>\n            by participating in the regulation of multiple genes.\n          <\/jats:p>","DOI":"10.1128\/iai.03161-14","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T01:52:45Z","timestamp":1425952365000},"page":"2089-2098","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":56,"title":["<i>hfq<\/i>\n            Plays Important Roles in Virulence and Stress Adaptation in Cronobacter sakazakii ATCC 29544"],"prefix":"10.1128","volume":"83","author":[{"given":"Seongok","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyelyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Molecular Science and Technology, Department of Applied Chemistry and Biological Engineering, Ajou University, Suwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangryeol","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-30-3-569"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01026-07"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-64"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65577-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15169-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.032292-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/501019"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00319.x"},{"key":"e_1_3_2_10_2","first-page":"128","article-title":"A case of neonatal meningitis caused by a yellow Enterobacter","volume":"12","author":"Joker RN","year":"1965","unstructured":"Joker RN, Norholm T, Siboni KE. 1965. 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