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The<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Listeria monocytogenes<\/jats:named-content>genome contains a gene,<jats:italic>lmo1800<\/jats:italic>, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that the<jats:italic>lmo1800<\/jats:italic>-encoded protein LipA is secreted by<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Listeria<\/jats:named-content>and displays tyrosine as well as lipid phosphatase activity<jats:italic>in vitro<\/jats:italic>. Bacteria lacking LipA are severely attenuated in virulence<jats:italic>in vivo<\/jats:italic>, thus revealing a so-far-undescribed enzymatic activity involved in<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Listeria<\/jats:named-content>infection.<\/jats:p>","DOI":"10.1128\/iai.05073-11","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T02:06:34Z","timestamp":1301364394000},"page":"2489-2498","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["LipA, a Tyrosine and Lipid Phosphatase Involved in the Virulence of Listeria monocytogenes"],"prefix":"10.1128","volume":"79","author":[{"given":"Renate","family":"Kastner","sequence":"first","affiliation":[{"name":"Max F. 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