{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:33:33Z","timestamp":1787016813868,"version":"build-2736575974"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Resistance to schistosomiasis is associated with increased levels of serum parasite-specific IgE. IgE exerts its functions through its cellular receptors, Fc\u03b5RI and Fc\u03b5RII\/CD23; however, its functional significance in humans requires further characterization. We previously reported that increased levels of CD23\n                    <jats:sup>+<\/jats:sup>\n                    B cells correlate with resistance to schistosomiasis in hyperexposed populations and sought to define their potential function and relationship with IgE. We found that CD23\n                    <jats:sup>+<\/jats:sup>\n                    B cells are a heterogeneous cell population with functional and phenotypic differences. Circulating CD23\n                    <jats:sup>+<\/jats:sup>\n                    B cells are uniquely activated in schistosomiasis and express the CD23b isoform and CXCR5, the homing receptor for lymphoid follicles. High CXCR5 expression by CD23\n                    <jats:sup>+<\/jats:sup>\n                    B cells was associated with the capacity to home to the cognate ligand CXCL13. CD23-bound IgE cross-linking increased surface expression of CXCR5, suggesting that CD23\n                    <jats:sup>+<\/jats:sup>\n                    B cells home directly into the lymphoid follicles upon antigen capture. As human schistosomiasis is an intravascular parasitic infection associated with a high antigenic burden in the blood, circulating CD23\n                    <jats:sup>+<\/jats:sup>\n                    B cells may play a role in the capture and shuttling of antigens directly to splenic follicles, highlighting a new role for circulating B cells. This function likely plays an important role in the development of protective immunity to infection with schistosomes.\n                  <\/jats:p>","DOI":"10.1128\/iai.05094-11","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T02:56:41Z","timestamp":1309229801000},"page":"3770-3777","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["CD23b Isoform Expression in Human Schistosomiasis Identifies a Novel Subset of Activated B Cells"],"prefix":"10.1128","volume":"79","author":[{"given":"Daniel","family":"Onguru","sequence":"first","affiliation":[{"name":"Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanMei","family":"Liang","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Elliot","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Mwinzi","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ganley-Leal","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35018581"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/358505a0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/653828"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.3610"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.9.1285"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.3222"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/430929"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80080-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761992000800014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363848"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh142"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101308"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb03314.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.04.571"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2169-2176.2006"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1473"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00007-3"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141103"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/367183a0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002709"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050811"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.10.6604"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1657"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01238.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09781-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8455-1"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.6.3139"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00114-X"},{"key":"e_1_3_2_31_2","first-page":"27","article-title":"CD23-mediated cell signalling","volume":"9","author":"Kolb J. 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