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All strains harbor two chromosomes, but 775 also harbors the virulence plasmid pJM1, which carries the anguibactin-producing and cognate transport genes, one of the main virulence factors of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. anguillarum<\/jats:named-content>. Genomic analysis identified eight genomic islands in chromosome 1 of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. anguillarum<\/jats:named-content>775(pJM1) and two in chromosome 2. Some of them carried potential virulence genes for the biosynthesis of O antigens, hemolysins, and exonucleases as well as others for sugar transport and metabolism. The majority of genes for essential cell functions and pathogenicity are located on chromosome 1. In contrast, chromosome 2 contains a larger fraction (59%) of hypothetical genes than does chromosome 1 (42%). Chromosome 2 also harbors a superintegron, as well as host \u201caddiction\u201d genes that are typically found on plasmids. Unique distinctive properties include homologues of type III secretion system genes in 96F, homologues of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. cholerae<\/jats:named-content><jats:italic>zot<\/jats:italic>and<jats:italic>ace<\/jats:italic>toxin genes in RV22, and the biofilm formation<jats:italic>syp<\/jats:italic>genes in<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. ordalii.<\/jats:named-content>Mobile genetic elements, some of them possibly originated in the pJM1 plasmid, were very abundant in 775, resulting in the silencing of specific genes, with only few insertions in the 96F and RV22 chromosomes.<\/jats:p>","DOI":"10.1128\/iai.05138-11","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T01:57:30Z","timestamp":1305597450000},"page":"2889-2900","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":99,"title":["Complete Genome Sequence of the Marine Fish Pathogen Vibrio anguillarum Harboring the pJM1 Virulence Plasmid and Genomic Comparison with Other Virulent Strains of V. anguillarum and V. ordalii"],"prefix":"10.1128","volume":"79","author":[{"given":"Hiroaki","family":"Naka","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela M.","family":"Dias","sequence":"additional","affiliation":[{"name":"Institute of Biology, Federal University of Rio de Janeiro, UFRJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics of Microorganisms, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dubay","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano L.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Institute of Biology, Federal University of Rio de Janeiro, UFRJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge H.","family":"Crosa","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1079\/9781845935542.0570","volume-title":"Fish diseases and disorders, vol. 3: viral, bacterial, and fungal infections","author":"Actis L. 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