{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:13:53Z","timestamp":1790439233056,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A new\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            species,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella microti<\/jats:named-content>\n            , has been isolated from wild rodents and found to be pathogenic in mice. The biological relevance of this new mouse pathogen is clear, as it allows us to study\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella<\/jats:named-content>\n            infection in a species-specific model. The course of infection in wild-type (wt) and immunodeficient mice that lack B (Jh), T and B (SCID), or T, B, and NK (SCID.Beige) cells was analyzed over 3 weeks. wt mice completely cleared bacteria from the liver and spleen after that time. However, SCID mice showed a much higher bacterial load in the spleen and liver than wt and Jh mice after 1 week and maintained the same level during the next 2 weeks. All mice tested survived for the 3 weeks. In contrast, the bacterial levels in mice that lacked NK cell activity progressively increased and these mice succumbed to infection after 16 to 18 days. Histopathology analysis of infected mice showed extensive areas of necrotic tissue and thrombosis in liver after 1 week in all infected SCID.Beige mice but were not seen in either SCID or wt animals. These processes were dramatically increased after 21 days, corresponding with the death of SCID.Beige animals. Our results indicate that T and\/or B cells are required for the control of infection with the mouse pathogen\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella microti<\/jats:named-content>\n            in liver and spleen but that NK cells are crucial for survival in the absence of B and T cells. In addition, they suggest that controlled granuloma formation is critical to clear this type of infection in wt mice.\n          <\/jats:p>","DOI":"10.1128\/iai.05542-11","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T05:54:53Z","timestamp":1312869293000},"page":"3934-3939","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice"],"prefix":"10.1128","volume":"79","author":[{"given":"Mar\u00eda P.","family":"Jim\u00e9nez de Bag\u00fc\u00e9s","sequence":"first","affiliation":[{"name":"Unidad de Sanidad Animal, Centro de Investigaci\u00f3n y Tecnolog\u00eda Agroalimentaria (CITA), Gobierno de Arag\u00f3n, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"de Martino","sequence":"additional","affiliation":[{"name":"Unidad de Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Unidad de Sanidad Animal, Centro de Investigaci\u00f3n y Tecnolog\u00eda Agroalimentaria (CITA), Gobierno de Arag\u00f3n, Zaragoza, Spain"},{"name":"Departamento Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Alcaraz","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Western University of Health Sciences, Pomona, California 91766"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Pardo","sequence":"additional","affiliation":[{"name":"Departamento Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain"},{"name":"Fundaci\u00f3n Arag\u00f3n I+D (ARAID), Aragon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-352"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v26.i5.30"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.6.647"},{"key":"e_1_3_2_5_2","first-page":"96","article-title":"Persistence of Brucella abortus in the livers of T cell-deficient nude mice","volume":"73","author":"Cheville N. 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