{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:37:13Z","timestamp":1764401833412},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1978,2,1]],"date-time":"1978-02-01T00:00:00Z","timestamp":255139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[1978,2]]},"abstract":"<jats:p>A lethal septicemia was induced in 11- and 12-day-old chicken embryos with intravenous inoculation of relatively small numbers of a clinical isolate (GBBHS-III-Bell) or a reference strain (GBBHS-III-D136-C) of group B beta-hemolytic streptococci (GBBHS). GBBHS-III-Bell was more virulent than GBBHS-III-D136-C, and 11-day-old chicken embryos were more susceptible than 12-day-old chicken embryos. Type-specific rabbit antisera protected the embryos from bacterial challenge, and this protective effect was absorbed with homologous but not heterologous GBBHS strains. A heterologous antiserum and normal rabbit sera provided some protection, which could be absorbed with either homologous or heterologous GBBHS strains. The chicken embryo is a suitable animal model for the study of infection and immunity with GBBHS type III.<\/jats:p>","DOI":"10.1128\/iai.19.2.481-485.1978","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T02:15:15Z","timestamp":1578017715000},"page":"481-485","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Chicken embryo model for type III group B beta-hemolytic streptococcal septicemia"],"prefix":"10.1128","volume":"19","author":[{"given":"J","family":"Tieffenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R R","family":"Kretschmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Padnos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S P","family":"Gotoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.19.2.481-485.1978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.19.2.481-485.1978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T21:02:26Z","timestamp":1646427746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.19.2.481-485.1978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,2]]}},"alternative-id":["10.1128\/iai.19.2.481-485.1978"],"URL":"https:\/\/doi.org\/10.1128\/iai.19.2.481-485.1978","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,2]]},"assertion":[{"value":"1978-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}