{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:24:49Z","timestamp":1779272689395,"version":"3.51.4"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1970,10,1]],"date-time":"1970-10-01T00:00:00Z","timestamp":23587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[1970,10]]},"abstract":"<jats:p>\n            Acute alloxan diabetic rabbits were used in a survey of the potential ability of\n            <jats:italic>Absidia, Cunninghamella, Mucor, Rhizopus, Syncephalastrum<\/jats:italic>\n            , and\n            <jats:italic>Thamnidium<\/jats:italic>\n            species to cause cerebral zygomycosis (phycomycosis, mucormycosis). Specifically, the correlation of thermotolerance with potential pathogenicity was studied. The test organisms fell into two groups: those able to grow well at 39 C on Sabouraud dextrose agar and those unable to grow at that temperature. Isolates unable to grow at 39 C were not pathogenic. The nonpathogens were\n            <jats:italic>C. elegans, M. jansenni, R. reflexus, R. stolonifer<\/jats:italic>\n            , and\n            <jats:italic>T. elegans<\/jats:italic>\n            . Two isolates of\n            <jats:italic>S. racemosum<\/jats:italic>\n            and one isolate of\n            <jats:italic>A. corymbifera<\/jats:italic>\n            , although able to grow well at 39 C in vitro, did not invade the brain or lungs of acutely diabetic rabbits. Three species of\n            <jats:italic>Rhizopus, R. chinensis, R. microsporus<\/jats:italic>\n            , and\n            <jats:italic>R. oligosporus<\/jats:italic>\n            , all of which grew at 39 C and which had not been previously known to cause cerebral zygomycosis, were as pathogenic as the only two previously implicated disease agents,\n            <jats:italic>R. arrhizus<\/jats:italic>\n            and\n            <jats:italic>R. oryzae<\/jats:italic>\n            . Studies were also carried out to determine whether animals inoculated with spores of selected zygomycetes many hours prior to the onset of acute diabetes would develop cerebral zygomycosis. Approximately 50% of the rabbits that became acutely diabetic 72 to 90 hr after receiving\n            <jats:italic>R. oryzae<\/jats:italic>\n            spores by nasal instillation succumbed to cerebral zygomycosis. Our study indicates that several members of the genus\n            <jats:italic>Rhizopus<\/jats:italic>\n            that grow well at 39 C or higher, other than\n            <jats:italic>R. arrhizus<\/jats:italic>\n            and\n            <jats:italic>R. oryzae<\/jats:italic>\n            , are potential etiological agents of cerebral zygomycosis.\n          <\/jats:p>","DOI":"10.1128\/iai.2.4.404-413.1970","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T05:22:40Z","timestamp":1577856160000},"page":"404-413","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Experimental Cerebral Zygomycosis in Alloxan-Diabetic Rabbits I. Relationship of Temperature Tolerance of Selected Zygomycetes to Pathogenicity"],"prefix":"10.1128","volume":"2","author":[{"given":"Donald J.","family":"Reinhardt","sequence":"first","affiliation":[{"name":"National Communicable Disease Center, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Kaplan","sequence":"additional","affiliation":[{"name":"National Communicable Disease Center, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libero","family":"Ajello","sequence":"additional","affiliation":[{"name":"National Communicable Disease Center, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.2.4.404-413.1970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.2.4.404-413.1970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:02:18Z","timestamp":1646485338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.2.4.404-413.1970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1970,10]]}},"alternative-id":["10.1128\/iai.2.4.404-413.1970"],"URL":"https:\/\/doi.org\/10.1128\/iai.2.4.404-413.1970","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,10]]},"assertion":[{"value":"1970-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}