{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:12:53Z","timestamp":1790863973805,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>BALB\/By mice given doses of D-galactosamine plus Staphylococcus aureus enterotoxin B die within 48 h of administration. The cause of death is a syndrome much like toxic shock syndrome in humans. We used this model to investigate the role of two cytokines, interleukin 6 and interleukin 11, which share the signal transducing subunit, gp130, of their respective receptors. We observed that pretreatment of mice with antibody to interleukin 6 increased mortality from 55% to nearly 90% (P &lt; 0.001), while pretreatment with either cytokine reduced death. The protection was dose dependent; however, interleukin 6 was about 10-fold more potent that interleukin 11. These data indicate that endogenous interleukin 6 plays a protective role in attenuating acute inflammatory responses; furthermore, interleukin 6 and interleukin 11 can abrogate T-cell activation due to triggering by superantigen. A possible clinical role for these cytokines in the treatment of toxic shock merits further investigation.<\/jats:p>","DOI":"10.1128\/iai.64.3.714-718.1996","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:57:23Z","timestamp":1578337043000},"page":"714-718","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model"],"prefix":"10.1128","volume":"64","author":[{"given":"B E","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Shortall","sequence":"additional","affiliation":[{"name":"Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J V","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.64.3.714-718.1996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.64.3.714-718.1996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T08:35:23Z","timestamp":1646469323000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.64.3.714-718.1996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1128\/iai.64.3.714-718.1996"],"URL":"https:\/\/doi.org\/10.1128\/iai.64.3.714-718.1996","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]},"assertion":[{"value":"1996-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}