{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T21:14:11Z","timestamp":1770844451273,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>The V antigen is a 37-kDa secreted polypeptide encoded on the 70-kb virulence plasmid of pathogenic Yersinia spp. Besides having regulatory functions, it is known to be a virulence factor and a protective antigen. DNA sequencing of the most common serotypes of human pathogenic Yersinia enterocolitica and Y. pseudotuberculosis revealed that two evolutionary distinct types of V antigen exist in Yersinia spp. One type is represented by Y. enterocolitica serotype 08 strains WA, WA-314, and NCTC 10938 (designated LcrV-YenO8); the other type comprises Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica serotypes O3, O9, and O5,27 (LcrV-Yps). A hypervariable region between amino acids 225 and 232 represents the main difference between the two types. By raising monospecific antisera against both types of V antigen (anti-rVO8 and anti-rVO3), we were able to demonstrate that, in general, passive immunization of mice against a challenge with yersiniae was possible with both anti-Y. enterocolitica V antigen sera. However, anti-V antigen serum was protective only if the immunizing V antigen was the same type as the V antigen produced by the infective strain. The failure of the American V antigen type represented by Y. enterocolitica serotype O8 to protect against Yersinia spp. carrying the other V antigen type (LcrV-Yps) could be an explanation for the presence of plague foci in American countries.<\/jats:p>","DOI":"10.1128\/iai.65.2.446-451.1997","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T19:13:51Z","timestamp":1578338031000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":91,"title":["Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen"],"prefix":"10.1128","volume":"65","author":[{"given":"A","family":"Roggenkamp","sequence":"first","affiliation":[{"name":"Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Geiger","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Leitritz","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kessler","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Heesemann","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer Institute for Hygiene and Microbiology, Ludwig Maximilian University of Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.65.2.446-451.1997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.65.2.446-451.1997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T09:04:40Z","timestamp":1646471080000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.65.2.446-451.1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1128\/iai.65.2.446-451.1997"],"URL":"https:\/\/doi.org\/10.1128\/iai.65.2.446-451.1997","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]},"assertion":[{"value":"1997-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}