{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:49:10Z","timestamp":1791020950960,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Colonization of the gastric mucosa by\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            is the major cause of gastroduodenal pathologies in humans. Studying the outcome of the humoral immune response directed against this gastric pathogen may contribute substantially to vaccine development and to the improvement of diagnostic techniques based on serology. By using two-dimensional gel electrophoresis, 29 proteins from\n            <jats:italic>H. pylori<\/jats:italic>\n            G27 were identified which strongly react with sera derived from\n            <jats:italic>H. pylori<\/jats:italic>\n            -infected patients suffering from different gastroduodenal pathologies. These antigens were characterized by mass spectrometry and proved to correspond to products of open reading frames predicted by the\n            <jats:italic>H. pylori<\/jats:italic>\n            genome sequence. The comparison of the antigenic patterns recognized by these sera revealed no association of specific\n            <jats:italic>H. pylori<\/jats:italic>\n            antigens with antibodies in patients with particular gastroduodenal pathologies.\n          <\/jats:p>","DOI":"10.1128\/iai.68.2.915-920.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"915-920","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":101,"title":["Identification of Immunodominant Antigens from\n            <i>Helicobacter pylori<\/i>\n            and Evaluation of Their Reactivities with Sera from Patients with Different Gastroduodenal Pathologies"],"prefix":"10.1128","volume":"68","author":[{"given":"Brigitte","family":"Kimmel","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Theodor-Boveri-Institut fu\u0308r Biowissenschaften, Lehrstuhl fu\u0308r Mikrobiologie, Universita\u0308t Wu\u0308rzburg, D-97074 Wu\u0308rzburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Bosserhoff","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Zentrum fu\u0308r Molekularbiologie, Universita\u0308t Heidelberg, D-69120 Heidelberg,2 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Frank","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Zentrum fu\u0308r Molekularbiologie, Universita\u0308t Heidelberg, D-69120 Heidelberg,2 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Gross","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Theodor-Boveri-Institut fu\u0308r Biowissenschaften, Lehrstuhl fu\u0308r Mikrobiologie, Universita\u0308t Wu\u0308rzburg, D-97074 Wu\u0308rzburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Goebel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Theodor-Boveri-Institut fu\u0308r Biowissenschaften, Lehrstuhl fu\u0308r Mikrobiologie, Universita\u0308t Wu\u0308rzburg, D-97074 Wu\u0308rzburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Beier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Theodor-Boveri-Institut fu\u0308r Biowissenschaften, Lehrstuhl fu\u0308r Mikrobiologie, Universita\u0308t Wu\u0308rzburg, D-97074 Wu\u0308rzburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/16495"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.15.4676-4683.1997"},{"key":"e_1_3_2_6_2","first-page":"56","article-title":"Therapy of H. pylori infection","volume":"13","author":"Buckley M. 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