{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:37:39Z","timestamp":1771569459751,"version":"3.50.1"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2000,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n As Lewis a (Le\n a<\/jats:sup>\n ) and Lewis b (Le\n b<\/jats:sup>\n ) blood group antigens are isoforms of Lewis x (Le\n x<\/jats:sup>\n ) and Lewis y (Le\n y<\/jats:sup>\n ) and are expressed in the gastric mucosa, we evaluated whether the patterns of expression of Le\n x<\/jats:sup>\n and Le\n y<\/jats:sup>\n on\n Helicobacter pylori<\/jats:italic>\n lipopolysaccharides reflected those of host expression of Le\n a<\/jats:sup>\n and Le\n b<\/jats:sup>\n . When 79 patients (secretors and nonsecretors) were examined for concordance between bacterial and host Le expression, no association was found (\u03c7\n 2<\/jats:sup>\n = 5.734, 3 df,\n P<\/jats:italic>\n = 0.125), nor was there a significant difference between the amount of Le\n x<\/jats:sup>\n or Le\n y<\/jats:sup>\n expressed on isolates from ulcer and chronic gastritis patients (\n P<\/jats:italic>\n > 0.05). Also, the effect of host and bacterial expression of Le antigens on bacterial colonization and the observed inflammatory response was assessed. In ulcer patients, Le\n x<\/jats:sup>\n expression was significantly related to neutrophil infiltration (\n r<\/jats:italic>\n s<\/jats:sub>\n = 0.481,\n P<\/jats:italic>\n = 0.024), whereas in chronic gastritis patients significant relationships were found between Le\n x<\/jats:sup>\n expression and\n H. pylori<\/jats:italic>\n colonization density (\n r<\/jats:italic>\n s<\/jats:sub>\n = 0.296,\n P<\/jats:italic>\n = 0.03), neutrophil infiltrate (\n r<\/jats:italic>\n s<\/jats:sub>\n = 0.409,\n P<\/jats:italic>\n = 0.001), and lymphocyte infiltrate (\n r<\/jats:italic>\n s<\/jats:sub>\n = 0.389,\n P<\/jats:italic>\n = 0.002). Furthermore, bacterial Le\n y<\/jats:sup>\n expression was related to neutrophil (\n r<\/jats:italic>\n s<\/jats:sub>\n = 0.271,\n P<\/jats:italic>\n = 0.033) and lymphocyte (\n r<\/jats:italic>\n s<\/jats:sub>\n = 0.277,\n P<\/jats:italic>\n = 0.029) infiltrates. Thus, although no evidence of concordance was found between bacterial and host expression of Le determinants, these antigens may be crucial for bacterial colonization, and the ensuing inflammatory response appears, at least in part, to be influenced by Le antigens.\n <\/jats:p>","DOI":"10.1128\/iai.68.2.937-941.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"937-941","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":89,"title":["Relationship of Blood Group Determinants on\n Helicobacter pylori<\/i>\n Lipopolysaccharide with Host Lewis Phenotype and Inflammatory Response"],"prefix":"10.1128","volume":"68","author":[{"given":"Michael A.","family":"Heneghan","sequence":"first","affiliation":[{"name":"Department of Medicine, Clinical Science Institute, University College Hospital Galway,1and"},{"name":"Laboratory of Molecular Biochemistry, Department of Microbiology,2 National University of Ireland, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciaran F.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Science Institute, University College Hospital Galway,1and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony P.","family":"Moran","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biochemistry, Department of Microbiology,2 National University of Ireland, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01281-X"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2031-2040.1996"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.3.351"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.720"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","unstructured":"Eidt\nS.\nStolte\nM.\nDifferences between Helicobacter associated gastritis in patients with duodenal ulcer pyloric ulcers gastric ulcers and gastritis without ulcer\nHelicobacter pylori gastritis and peptic ulcer.\nMalfertheiner\nP.\nDitschuneit\nH.\n1990\n228\n236\nSpringer-Verlag\nBerlin Germany","DOI":"10.1007\/978-3-642-75315-2_35"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1989.tb02417.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3925"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1998.tb01135.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.154.1.269-277.1983"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199704000-00009"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/87.1.129"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01268.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800048366"},{"key":"e_1_3_1_15_2","first-page":"219","article-title":"Immunohistologic pattern of type 1 (Lea, Leb) and type 2 (X, Y, H) blood group-related antigens in the human pyloric and duodenal mucosa","volume":"53","author":"Mollicone R.","year":"1985","unstructured":"Mollicone R. Bara J. LePendu J. Oriol R. Immunohistologic pattern of type 1 (Lea, Leb) and type 2 (X, Y, H) blood group-related antigens in the human pyloric and duodenal mucosa.Lab. Investig.531985219227","journal-title":"Lab. Investig."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1995.tb00043.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609094530"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/096805199600300611"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70582-7"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800050937"},{"key":"e_1_3_1_21_2","first-page":"745","article-title":"Expression of Lewisa, Lewisb, Lewisx, Lewisy, sialyl-Lewisa and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue","volume":"49","author":"Sakamoto J.","year":"1989","unstructured":"Sakamoto J. Wantanabe T. Tokumara T. Takagi H. Nakazato H. Lloyd K. O. Expression of Lewisa, Lewisb, Lewisx, Lewisy, sialyl-Lewisa and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue.Cancer Res.491989745752","journal-title":"Cancer Res."},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.9.2196-2200.1996"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70082-4"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1997.00164.x"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.11.4598-4605.1996"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322503"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.68.2.937-941.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.68.2.937-941.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:22:20Z","timestamp":1646443340000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.68.2.937-941.2000"}},"subtitle":[],"editor":[{"given":"V. A.","family":"Fischetti","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1128\/IAI.68.2.937-941.2000"],"URL":"https:\/\/doi.org\/10.1128\/iai.68.2.937-941.2000","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"1999-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}