{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:50:14Z","timestamp":1790898614894,"version":"4.1.0"},"reference-count":74,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To determine the naturally occurring immunological responses to the<jats:italic>Schistosoma mansoni<\/jats:italic>antigens paramyosin, IrV-5, Sm-23 (MAP-3), and triose phosphate isomerase (MAP-4), a total of 119 subjects from an area of endemicity for schistosomiasis, including \u201cresistant\u201d subjects (<jats:italic>n<\/jats:italic>= 17) were evaluated. Specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, and IgA levels for each of the antigens and the cytokine profile in culture supernatants from antigen-stimulated peripheral blood mononuclear cells (PBMC) were determined. Although all the subjects had a high degree of contaminated water exposure, their infection levels were variable (0 to 1,128 eggs\/g of stool). There were direct correlations between infection levels and levels of SWAP- and paramyosin-specific IgG1 and IgG4 (<jats:italic>P<\/jats:italic>&lt; 0.05). However, an inverse correlation between infection levels and specific IgG2 to IrV-5 (<jats:italic>P<\/jats:italic>&lt; 0.01) was observed. The evaluation of the cytokine profile (interleukin 5 [IL-5], IL-10, gamma interferon [IFN-\u03b3], and tumor necrosis factor alpha) in response to these antigens showed inverse correlations between the degree of infection and IFN-\u03b3 levels in PBMC supernatants stimulated with paramyosin (<jats:italic>P<\/jats:italic>&lt; 0.05) and IrV-5 (<jats:italic>P<\/jats:italic>&lt; 0.01). Additionally, inverse correlations between the degree of infection and IL-5 levels in MAP-3- and MAP-4-stimulated PBMC supernatants (<jats:italic>P<\/jats:italic>&lt; 0.01) were found. Logistic regression analysis was performed to adjust the results of cytokine profile by age. IL-5 production in MAP-3-stimulated PBMC supernatants was associated with lower infection levels (odds ratio = 11.2 [95% confidence interval, 2.7 to 45.8]).<\/jats:p>","DOI":"10.1128\/iai.68.5.2797-2803.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"2797-2803","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":75,"title":["Human Immune Responses to<i>Schistosoma mansoni<\/i>Vaccine Candidate Antigens"],"prefix":"10.1128","volume":"68","author":[{"given":"Ame\u0301lia","family":"Ribeiro de Jesus","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Servic\u0327o de Imunologia, Hospital Universita\u0301rio Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilma","family":"Arau\u0301jo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Servic\u0327o de Imunologia, Hospital Universita\u0301rio Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oli\u0301via","family":"Bacellar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Servic\u0327o de Imunologia, Hospital Universita\u0301rio Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301a","family":"Magalha\u0303es","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Servic\u0327o de Imunologia, Hospital Universita\u0301rio Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Pearce","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Microbiology, Immunology and Parasitology, Cornell University College of Veterinary Medicine, Ithaca, New York2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Harn","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts3; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Strand","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Servic\u0327o de Imunologia, Hospital Universita\u0301rio Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil1;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1996.d01-49.x"},{"key":"e_1_3_2_3_2","first-page":"60","article-title":"Prospects of vaccination against schistosomiasis","volume":"76","author":"Bergquist R.","year":"1990","unstructured":"Bergquist R. Prospects of vaccination against schistosomiasis.Scand. J. Infect. Dis. Suppl.7619906071","journal-title":"Scand. J. Infect. Dis. Suppl."},{"key":"e_1_3_2_4_2","first-page":"69","article-title":"Estudo de vari\u00e1veis que podem influenciar na evolu\u00e7\u00e3o da esquistossomose mans\u00f4nica: efeito da terap\u00eautica espec\u0131\u0301fica e da interrup\u00e7\u00e3o da transmiss\u00e3o","volume":"26","author":"Bina J. C.","year":"1997","unstructured":"Bina J. C. Estudo de vari\u00e1veis que podem influenciar na evolu\u00e7\u00e3o da esquistossomose mans\u00f4nica: efeito da terap\u00eautica espec\u0131\u0301fica e da interrup\u00e7\u00e3o da transmiss\u00e3o.Rev. Patol. Trop.26199769128","journal-title":"Rev. Patol. Trop."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90391-8"},{"key":"e_1_3_2_6_2","first-page":"197","article-title":"Immunity and morbidity in human schistosomiasis mansoni","volume":"46","author":"Butterworth A. E.","year":"1994","unstructured":"Butterworth A. E. Curry A. J. Dunne D. W. Fulford A. J. Kimani G. Kariuki H. C. Klumpp R. Koech D. Mbugua G. Ouma J. H. Immunity and morbidity in human schistosomiasis mansoni.Trop. Geogr. Med.461994197208","journal-title":"Trop. Geogr. Med."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/252503a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/256727a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4049\/jimmunol.122.1.221","article-title":"Damage to schistosomula of schistosoma mansoni induced directly by eosinophil major basic protein","volume":"122","author":"Butterworth A. E.","year":"1979","unstructured":"Butterworth A. E. Wassom D. L. Gleich G. J. Loegering D. A. David J. R. Damage to schistosomula of schistosoma mansoni induced directly by eosinophil major basic protein.J. Immunol.1221979221229","journal-title":"J. Immunol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3317823"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(83)90191-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761995000200019"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.4049\/jimmunol.126.5.1764","article-title":"Evidence for IgE-dependent cytotoxicity by rat eosinophils","volume":"126","author":"Capron M.","year":"1981","unstructured":"Capron M. Bazin H. Joseph M. Capron A. Evidence for IgE-dependent cytotoxicity by rat eosinophils.J. Immunol.126198117641768","journal-title":"J. Immunol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009216"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(86)90158-4"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90225-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90334-9"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.238"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1989.40.50"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230125"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90523-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(91)90446-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.1000"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.4049\/jimmunol.140.8.2727","article-title":"Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen","volume":"140","author":"Dessein A. J.","year":"1988","unstructured":"Dessein A. J. Begley M. Demeure C. Caillol D. Fueri J. dos Reis M. G. Andrade Z. A. Prata A. Bina J. C. Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen.J. Immunol.140198827272736","journal-title":"J. Immunol."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220622"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761992000800014"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91041-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761992000800013"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/349243a0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(89)90015-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4049\/jimmunol.148.2.562","article-title":"A protective monoclonal antibody specifically recognizes and alters the catalytic activity of schistosome triose-phosphate isomerase","volume":"148","author":"Harn D. A.","year":"1992","unstructured":"Harn D. A. Gu W. Oligino L. D. Mitsuyama M. Gebremichael A. Richter D. A protective monoclonal antibody specifically recognizes and alters the catalytic activity of schistosome triose-phosphate isomerase.J. Immunol.1481992562567","journal-title":"J. Immunol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.4049\/jimmunol.135.3.2115","article-title":"Schistosoma mansoni: detection by monoclonal antibody of a 22,000-dalton surface membrane antigen which may be blocked by host molecules on lung stage parasites","volume":"135","author":"Harn D. A.","year":"1985","unstructured":"Harn D. A. Mitsuyama M. Huguenel E. D. David J. R. Schistosoma mansoni: detection by monoclonal antibody of a 22,000-dalton surface membrane antigen which may be blocked by host molecules on lung stage parasites.J. Immunol.135198521152120","journal-title":"J. Immunol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(85)90075-1"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.4049\/jimmunol.138.5.1571","article-title":"Evidence that a protective membrane epitope is involved in early but not late phase immunity in Schistosoma mansoni","volume":"138","author":"Harn D. A.","year":"1987","unstructured":"Harn D. A. Quinn J. J. Cianci C. M. Ko A. I. Evidence that a protective membrane epitope is involved in early but not late phase immunity in Schistosoma mansoni.J. Immunol.138198715711580","journal-title":"J. Immunol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.4049\/jimmunol.163.2.927","article-title":"Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni","volume":"163","author":"Hoffmann K. F.","year":"1999","unstructured":"Hoffmann K. F. James S. L. Cheever A. W. Wynn T. A. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni.J. Immunol.1631999927938","journal-title":"J. Immunol."},{"key":"e_1_3_2_36_2","first-page":"115","article-title":"The schistosomiasis problem in the world: results of a WHO questionnaire survey","volume":"59","author":"Iarotski L. S.","year":"1981","unstructured":"Iarotski L. S. Davis A. The schistosomiasis problem in the world: results of a WHO questionnaire survey.Bulletin of the W. H. O.591981115127","journal-title":"Bulletin of the W. H. O."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(87)90170-6"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.4049\/jimmunol.136.10.3864","article-title":"Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. II. Response of mouse strains with selective immune defects","volume":"136","author":"James S. L.","year":"1986","unstructured":"James S. L. DeBlois L. A. Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. II. Response of mouse strains with selective immune defects.J. Immunol.136198638643871","journal-title":"J. Immunol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00932.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90032-N"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.4049\/jimmunol.140.8.2753","article-title":"The influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis","volume":"140","author":"James S. L.","year":"1988","unstructured":"James S. L. Pearce E. J. The influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis.J. Immunol.140198827532759","journal-title":"J. Immunol."},{"key":"e_1_3_2_42_2","unstructured":"James S. L. Scott P. Induction of cell mediated immunity as a strategy for vaccination against parasites. 1988 Alan R. Liss New York N.Y"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4049\/jimmunol.162.1.345","article-title":"Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-g-dependent effector mechanisms","volume":"162","author":"Jankovic D.","year":"1998","unstructured":"Jankovic D. Wynn T. A. Kullberg M. C. Hieny S. Caspar P. James S. Cheever A. W. Sher A. Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-g-dependent effector mechanisms.J. Immunol.1621998345351","journal-title":"J. Immunol."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.231"},{"key":"e_1_3_2_45_2","first-page":"295","article-title":"Coprological diagnosis of schistosomiasis. I. Evaluation of quantitative techniques","volume":"10","author":"Katz N.","year":"1968","unstructured":"Katz N. Chaia G. Coprological diagnosis of schistosomiasis. I. Evaluation of quantitative techniques.Rev. Inst. Med. Trop. Sao Paulo101968295298","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2307\/3277532"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2307\/3276534"},{"key":"e_1_3_2_48_2","first-page":"55","article-title":"Correlation between symptomatology and intensity of Schistosoma mansoni infection in inhabitants from endemic areas in Minas Gerais State\u2014Brazil","volume":"11","author":"Katz N.","year":"1975","unstructured":"Katz N. Zicker F. Correlation between symptomatology and intensity of Schistosoma mansoni infection in inhabitants from endemic areas in Minas Gerais State\u2014Brazil.Brasilia Medica.1119755559","journal-title":"Brasilia Medica."},{"key":"e_1_3_2_49_2","unstructured":"Kemeny D. M. A practical guide to ELISA. 1991 Pergamon Press New York N.Y"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.4049\/jimmunol.137.11.3593","article-title":"Immunochemical characterization and purification of Sm-97, a Schistosoma mansoni antigen monospecifically recognized by antibodies from mice protectively immunized with a nonliving vaccine","volume":"137","author":"Pearce E. J.","year":"1986","unstructured":"Pearce E. J. James S. L. Dalton J. Barrall A. Ramos C. Strand M. Sher A. Immunochemical characterization and purification of Sm-97, a Schistosoma mansoni antigen monospecifically recognized by antibodies from mice protectively immunized with a nonliving vaccine.J. Immunol.137198635933600","journal-title":"J. Immunol."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5678"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.4049\/jimmunol.131.3.1466","article-title":"The immunological response of congenitally athymic rats to Schistosoma mansoni infection","volume":"131","author":"Phillips S. M.","year":"1983","unstructured":"Phillips S. M. Bentley A. G. Linette G. Doughty B. Capron M. The immunological response of congenitally athymic rats to Schistosoma mansoni infection.J. Immunol.131198314661474","journal-title":"J. Immunol."},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.4049\/jimmunol.139.3.919","article-title":"In vivo T cell depletion regulates resistance and morbidity in murine schistosomiasis","volume":"139","author":"Phillips S. M.","year":"1987","unstructured":"Phillips S. M. Linette G. P. Doughty B. L. Byram J. E. von Lichtenberg F. In vivo T cell depletion regulates resistance and morbidity in murine schistosomiasis.J. Immunol.1391987919926","journal-title":"J. Immunol."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(93)90221-I"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4049\/jimmunol.152.1.193","article-title":"T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase","volume":"152","author":"Reynolds S. R.","year":"1994","unstructured":"Reynolds S. R. Dahl C. E. Harn D. A. T and B epitope determination and analysis of multiple antigenic peptides for the Schistosoma mansoni experimental vaccine triose-phosphate isomerase.J. Immunol.1521994193200","journal-title":"J. Immunol."},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.4049\/jimmunol.149.12.3995","article-title":"T and B cell epitope mapping of SM23, an integral membrane protein of Schistosoma mansoni","volume":"149","author":"Reynolds S. R.","year":"1992","unstructured":"Reynolds S. R. Shoemaker C. B. Harn D. A. T and B cell epitope mapping of SM23, an integral membrane protein of Schistosoma mansoni.J. Immunol.149199239954001","journal-title":"J. Immunol."},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211106"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220816"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.4049\/jimmunol.128.4.1880","article-title":"Mechanisms of protective immunity against Schistosoma mansoni in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement","volume":"128","author":"Sher A.","year":"1982","unstructured":"Sher A. Hieny S. James S. Asofsky R. Mechanisms of protective immunity against Schistosoma mansoni in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement.J. Immunol.128198218801884","journal-title":"J. Immunol."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072255"},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.4049\/jimmunol.136.10.3878","article-title":"Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. IV. Fractionation and antigenic properties of a soluble adult worm immunoprophylactic activity","volume":"136","author":"Sher A.","year":"1986","unstructured":"Sher A. Pearce E. Hieny S. James S. Induction of protective immunity against Schistosoma mansoni by a nonliving vaccine. IV. Fractionation and antigenic properties of a soluble adult worm immunoprophylactic activity.J. Immunol.136198638783883","journal-title":"J. Immunol."},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1842"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1996.d01-115.x"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.4049\/jimmunol.149.11.3654","article-title":"Monoclonal antibody to IFN-gamma modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae","volume":"149","author":"Smythies L. E.","year":"1992","unstructured":"Smythies L. E. Coulson P. S. Wilson R. A. Monoclonal antibody to IFN-gamma modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae.J. Immunol.149199236543658","journal-title":"J. Immunol."},{"key":"e_1_3_2_65_2","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.4049\/jimmunol.148.5.1512","article-title":"T cell-derived cytokines associated with pulmonary immune mechanisms in mice vaccinated with irradiated cercariae of Schistosoma mansoni","volume":"148","author":"Smythies L. E.","year":"1992","unstructured":"Smythies L. E. Pemberton R. M. Coulson P. S. Mountford A. P. Wilson R. A. T cell-derived cytokines associated with pulmonary immune mechanisms in mice vaccinated with irradiated cercariae of Schistosoma mansoni.J. Immunol.148199215121518","journal-title":"J. Immunol."},{"key":"e_1_3_2_66_2","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.4049\/jimmunol.151.9.4782","article-title":"Protective immunity in baboons vaccinated with a recombinant antigen or radiation-attenuated cercariae of Schistosoma mansoni is antibody-dependent","volume":"151","author":"Soisson L. A.","year":"1993","unstructured":"Soisson L. A. Reid G. D. Farah I. O. Nyindo M. Strand M. Protective immunity in baboons vaccinated with a recombinant antigen or radiation-attenuated cercariae of Schistosoma mansoni is antibody-dependent.J. Immunol.151199347824789","journal-title":"J. Immunol."},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1993.1111"},{"key":"e_1_3_2_68_2","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.4049\/jimmunol.149.11.3612","article-title":"Induction of protective immunity in mice using a 62-kDa recombinant fragment of a Schistosoma mansoni surface antigen","volume":"149","author":"Soisson L. M.","year":"1992","unstructured":"Soisson L. M. Masterson C. P. Tom T. D. McNally M. T. Lowell G. H. Strand M. Induction of protective immunity in mice using a 62-kDa recombinant fragment of a Schistosoma mansoni surface antigen.J. Immunol.149199236123620","journal-title":"J. Immunol."},{"key":"e_1_3_2_69_2","first-page":"75","article-title":"Characterization and cloning of Schistosoma mansoni immunogens recognized by protective antibodies","volume":"12","author":"Strand M.","year":"1987","unstructured":"Strand M. Dalton J. P. Tom T. D. Characterization and cloning of Schistosoma mansoni immunogens recognized by protective antibodies.Acta Trop. Suppl.1219877582","journal-title":"Acta Trop. Suppl."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761987000800021"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.269"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761995000200022"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb00895.x"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235265"},{"key":"e_1_3_2_75_2","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4049\/jimmunol.142.4.1342","article-title":"Protective immunity in mice vaccinated with the Schistosoma mansoni P-28-1 antigen","volume":"142","author":"Wolowczuk I.","year":"1989","unstructured":"Wolowczuk I. Auriault C. Gras-Masse H. Vendeville C. Balloul J.-M. Tartar A. Capron A. Protective immunity in mice vaccinated with the Schistosoma mansoni P-28-1 antigen.J. Immunol.142198913421350","journal-title":"J. Immunol."}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.68.5.2797-2803.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.68.5.2797-2803.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T15:18:44Z","timestamp":1682263124000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.68.5.2797-2803.2000"}},"subtitle":[],"editor":[{"given":"R. N.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1128\/IAI.68.5.2797-2803.2000"],"URL":"https:\/\/doi.org\/10.1128\/iai.68.5.2797-2803.2000","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]},"assertion":[{"value":"1999-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}