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Treatment with IL-10 during the course of a primary infection significantly decreased the number of bacteria in the spleen and did not affect the number in the liver. During a secondary infection in immune mice treated with IL-10, the number of bacteria was significantly lower in the spleen but significantly higher in the liver in comparison to mock-treated immune mice. IL-10 treatment during a primary<jats:italic>Listeria<\/jats:italic>infection decreased the concentration of gamma interferon (IFN-\u03b3) in plasma and the toxoplasmastatic activity of macrophages, whereas it increased the percentage of mildly CD3-positive T cells in the spleen. During a secondary infection, the concentration of IFN-\u03b3 in plasma was decreased on day 1 but remained unaffected during later days of infection. From these results, we conclude that IL-10 has different effects on the proliferation of<jats:italic>L. monocytogenes<\/jats:italic>in the spleen and liver during primary and secondary<jats:italic>Listeria<\/jats:italic>infections.<\/jats:p>","DOI":"10.1128\/iai.68.8.4666-4672.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"4666-4672","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Interleukin-10 Has Different Effects on Proliferation of<i>Listeria monocytogenes<\/i>in Livers and Spleens of Mice"],"prefix":"10.1128","volume":"68","author":[{"given":"Janneke N.","family":"Samsom","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akke","family":"Annema","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minke F.","family":"Geertsma","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A. 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