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To determine if CD4<jats:sup>+<\/jats:sup>T cells regulate migration of neutrophils and eosinophils into the cornea, CD4<jats:sup>+<\/jats:sup>cells were depleted using monoclonal antibody GK1.5 before intrastromal injection of parasite antigens. Depletion of CD4<jats:sup>+<\/jats:sup>cells abrogated corneal opacification at later but not early stages of disease. Consistent with this observation, CD4 depletion significantly impaired recruitment of eosinophils to the cornea but had no effect on neutrophils. These data indicate that CD4<jats:sup>+<\/jats:sup>T cells mediate sustained<jats:italic>O. volvulus<\/jats:italic>keratitis by regulating eosinophil recruitment to the cornea.<\/jats:p>","DOI":"10.1128\/iai.68.9.5459-5461.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:18Z","timestamp":1027763898000},"page":"5459-5461","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["CD4<sup>+<\/sup>Depletion Selectively Inhibits Eosinophil Recruitment to the Cornea and Abrogates<i>Onchocerca volvulus<\/i>Keratitis (River Blindness)"],"prefix":"10.1128","volume":"68","author":[{"given":"Laurie R.","family":"Hall","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departments ofMedicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussuf T.","family":"Kaifi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofMedicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Diaconu","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Opthalmology,2 Division of Geographic Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Pearlman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofMedicine1 and"},{"name":"<!--label omitted: 2-->Opthalmology,2 Division of Geographic Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1994.1316"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.4049\/jimmunol.163.9.4970","article-title":"An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell deficient (\u03bcMT) mice fail to develop Th2-dependent, helminth-mediated keratitis","volume":"163","author":"Hall L. 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