{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:33:17Z","timestamp":1774125197675,"version":"3.50.1"},"reference-count":7,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We present evidence that\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.\n          <\/jats:p>","DOI":"10.1128\/iai.69.2.1175-1177.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:19Z","timestamp":1027764079000},"page":"1175-1177","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":112,"title":["Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to\n            <i>Bacillus anthracis<\/i>\n            Lethal Toxin"],"prefix":"10.1128","volume":"69","author":[{"given":"James L.","family":"Erwin","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Headquarters,1"},{"name":"<!--label omitted: 2-->Division of Virology,2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"DaSilva","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Division of Toxinology,3 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Division of Toxinology,3 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen F.","family":"Little","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Division of Bacteriology,4 United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702\u20135011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur M.","family":"Friedlander","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Headquarters,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran C.","family":"Chanh","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Headquarters,1"},{"name":"<!--label omitted: 2-->Division of Virology,2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.734"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4687"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38364-3"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10277"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01502-1"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.11.6274"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9040"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.69.2.1175-1177.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.69.2.1175-1177.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T02:03:39Z","timestamp":1646445819000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.69.2.1175-1177.2001"}},"subtitle":[],"editor":[{"given":"J. D.","family":"Clements","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1128\/IAI.69.2.1175-1177.2001"],"URL":"https:\/\/doi.org\/10.1128\/iai.69.2.1175-1177.2001","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]},"assertion":[{"value":"2000-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}